This randomized phase II trial studies how well chemotherapy before surgery and radiation therapy works compared to surgery and radiation therapy alone in treating patients with nasal and paranasal sinus cancer that can be removed by surgery. Drugs used in chemotherapy, such as docetaxel, cisplatin, and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy before surgery and radiation therapy may make the tumor smaller and reduce the amount of normal tissue that needs to be removed and treated with radiation.
Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7, Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7
This randomized phase II trial studies how well chemotherapy before surgery and radiation therapy works compared to surgery and radiation therapy alone in treating patients with nasal and paranasal sinus cancer that can be removed by surgery. Drugs used in chemotherapy, such as docetaxel, cisplatin, and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy before surgery and radiation therapy may make the tumor smaller and reduce the amount of normal tissue that needs to be removed and treated with radiation.
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
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University of Arizona Cancer Center-Orange Grove Campus, Tucson, Arizona, United States, 85704
Banner University Medical Center - Tucson, Tucson, Arizona, United States, 85719
University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States, 85719
Mercy Hospital Fort Smith, Fort Smith, Arkansas, United States, 72903
UC San Diego Moores Cancer Center, La Jolla, California, United States, 92093
Stanford Cancer Institute Palo Alto, Palo Alto, California, United States, 94304
VA Palo Alto Health Care System, Palo Alto, California, United States, 94304
Smilow Cancer Center/Yale-New Haven Hospital, New Haven, Connecticut, United States, 06510
Yale University, New Haven, Connecticut, United States, 06520
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida, United States, 33146
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
No
ECOG-ACRIN Cancer Research Group,
Nabil Saba, PRINCIPAL_INVESTIGATOR, ECOG-ACRIN Cancer Research Group
2029-03-31