RECRUITING

Autologous Ovarian Tissue Transplantation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.

Official Title

Autologous Ovarian Tissue Transplantation

Quick Facts

Study Start:2021-03-01
Study Completion:2027-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03496636

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Previously cryopreserved ovarian tissue
  2. * Ovarian insufficiency and/or candidate for pregnancy
  3. * Good health
  4. * Oncologist's clearance
  1. * Patients considered to be high risk for surgical complications
  2. * Women with contraindication for pregnancy if goal is to achieve pregnancy
  3. * Women positive for the BRCA mutations
  4. * Women with a history of leukemia, ovarian cancer or a cancer that likely involved ovaries at the time of ovarian tissue collection
  5. * Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
  6. * Current pregnancy

Contacts and Locations

Study Contact

Rachel Neelley
CONTACT
412-641-7475
fertilitypreservation@upmc.edu

Principal Investigator

Kyle Orwig, PhD
PRINCIPAL_INVESTIGATOR
University of Pittsburgh/University of Pittsburgh Medical Center

Study Locations (Sites)

Magee-Womens Hospital
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Kyle Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh/University of Pittsburgh Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-03-01
Study Completion Date2027-09-01

Study Record Updates

Study Start Date2021-03-01
Study Completion Date2027-09-01

Terms related to this study

Keywords Provided by Researchers

  • Ovary
  • Transplant

Additional Relevant MeSH Terms

  • Primary Ovarian Insufficiency
  • Female Infertility