The Venous Distension Reflex and Orthostatic Hypertension

Description

This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).

Conditions

Blood Pressure

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Study Overview

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Study Details

Study overview

This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).

The Venous Distension Reflex and Orthostatic Hypertension

The Venous Distension Reflex and Orthostatic Hypertension

Condition
Blood Pressure
Intervention / Treatment

-

Contacts and Locations

Hershey

Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States, 17033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Are capable of giving informed consent
  • * Are of any race or ethnicity
  • * Are fluent in written and spoken English
  • * Whose history and physical exam did not uncover any exclusion criteria
  • * Are 18 years of age
  • * Systolic BP (SBP) during standing is at least 10 mmHg \> the supine SBP
  • * Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED
  • * The change in SBP by standing is within ± 5 mmHg from the supine SBP
  • * Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP
  • * Free of acute or chronic medical conditions
  • * Age \< 18 years of age
  • * Are a pregnant or nursing woman
  • * Are a prisoner or institutionalized individual or unable to consent
  • * Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension
  • * Have orthostatic hypotension or a history of syncope
  • * Current smoker
  • * History of blood clots

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Milton S. Hershey Medical Center,

Jian Cui, PRINCIPAL_INVESTIGATOR, Penn State College of Medicine

Study Record Dates

2025-06-30