OCT in Diagnosis of Irregular Corneas

Description

This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities. 2. Develop OCT metrics for more sensitive detection of keratoconus progression. 3. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.

Conditions

Keratoconus, Corneal Opacity, Corneal Dystrophy

Talk to us

Study Overview

On this page

Study Details

Study overview

This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities. 2. Develop OCT metrics for more sensitive detection of keratoconus progression. 3. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.

Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas

OCT in Diagnosis of Irregular Corneas

Condition
Keratoconus
Intervention / Treatment

-

Contacts and Locations

Portland

Humberto Martinez, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Keratoconus:
  • 1. CDVA ≥ 20/25 in the better eye; and both of the following in the worse eye
  • 2. Topography characteristic of keratoconus or pellucid marginal degeneration
  • * Contact lens-related corneal warpage:
  • 1. Contact lens use; and
  • 2. Topography irregularities
  • * Dry eye:
  • 1. Symptoms of dry eye documented by Ocular Surface Disease Index (OSDI) questionnaire score ≥ 30; and
  • 2. Topography irregularities
  • 3. Presence of punctate epithelial erosion on exam with surface staining
  • 4. Aqueous deficiency or evaporative dry eye
  • * Epithelial basement membrane dystrophy (EBMD):
  • 1. Negative corneal fluorescein staining; and
  • 2. Corneal opacities; and
  • 3. Topography irregularities
  • * Stromal addition or subtraction:
  • 1. Scars; or
  • 2. Salzmann's degeneration; or
  • 3. Stromal dystrophies; or
  • 4. Complication (visual complaints) after LASIK or photorefractive keratectomy (PRK)
  • * Stromal distortion:
  • 1. Radial keratectomy (RK); or
  • 2. Corneal transplants.
  • * Normal controls:
  • 1. Healthy eyes with no previous eye procedures/surgeries.
  • * Inability to give informed consent.
  • * Inability to maintain fixation for OCT imaging.
  • * Inability to commit to required study visits.
  • * Eyes with concurrent cataract, retinal disease, glaucoma, or other eye conditions that may limit the visual outcome after surgery.
  • * Previous corneal surgeries if considered as a keratoconus participant.
  • * Pregnancy or breastfeeding.

Ages Eligible for Study

14 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Oregon Health and Science University,

Yan Li, PhD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2026-04