DNA Methylation and Vascular Function

Description

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Conditions

Obesity, Vascular Dysfunction

Study Overview

Study Details

Study overview

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight Loss

DNA Methylation and Vascular Function

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Illinois at Chicago, Chicago, Illinois, United States, 60612

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * BMI ≥ 35 kg/m2
  • * Between ages 18-50 years
  • * Not pregnant
  • * Approved for a bariatric surgery
  • * To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
  • * Pregnant women will be excluded, as they will not be eligible for bariatric surgery
  • * Current smokers
  • * Currently abusing alcohol or drugs

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Illinois at Chicago,

Abeer Mohamed, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Illinois at Chicago

Study Record Dates

2025-08-31