RECRUITING

DNA Methylation and Vascular Function

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Official Title

DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight Loss

Quick Facts

Study Start:2019-10-11
Study Completion:2025-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03527420

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * BMI ≥ 35 kg/m2
  2. * Between ages 18-50 years
  3. * Not pregnant
  4. * Approved for a bariatric surgery
  1. * To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
  2. * Pregnant women will be excluded, as they will not be eligible for bariatric surgery
  3. * Current smokers
  4. * Currently abusing alcohol or drugs

Contacts and Locations

Study Contact

Abeer Mohamed, MD, PhD
CONTACT
3127539998
amahmo4@uic.edu

Principal Investigator

Abeer Mohamed, MD, PhD
PRINCIPAL_INVESTIGATOR
University of Illinois at Chicago

Study Locations (Sites)

University of Illinois at Chicago
Chicago, Illinois, 60612
United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

  • Abeer Mohamed, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Illinois at Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-10-11
Study Completion Date2025-08-31

Study Record Updates

Study Start Date2019-10-11
Study Completion Date2025-08-31

Terms related to this study

Keywords Provided by Researchers

  • Obesity
  • DNA methylation
  • Exercise
  • Weight loss
  • Bariatric
  • Macrovascular
  • Microvascular
  • Epigenetics
  • Adipose tissue
  • Adipocytokines
  • Inflammation
  • Cardiovascular

Additional Relevant MeSH Terms

  • Obesity
  • Vascular Dysfunction