Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

Description

This study will measure plasma concentrations of bivalirudin in pediatric patients undergoing cardiac catheterization, cardiac surgical procedures utilizing cardiopulmonary bypass (CPB), or extracorporeal support with ECMO, ventricular support devices (VAD) or lung-assist devices (LAD). The aim is to understand the pharmacokinetics of bivalirudin in these settings.

Conditions

Drug Effect

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Study Overview

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Study Details

Study overview

This study will measure plasma concentrations of bivalirudin in pediatric patients undergoing cardiac catheterization, cardiac surgical procedures utilizing cardiopulmonary bypass (CPB), or extracorporeal support with ECMO, ventricular support devices (VAD) or lung-assist devices (LAD). The aim is to understand the pharmacokinetics of bivalirudin in these settings.

Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

Condition
Drug Effect
Intervention / Treatment

-

Contacts and Locations

Boston

Boston Children's Hospital, Boston, Massachusetts, United States, 02116

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * pediatric patient (age less than 18 years)
  • * weight \> 3kg
  • * scheduled to undergo 1) cardiac catheterization, 2)cardiac surgical procedure utilizing CPB, and/or 3) the institution of extracorporeal support
  • * must already require the administration of bivalirudin as part of their treatment plan
  • * Age equal to or greater than 18 years,
  • * weight less than 3kg
  • * end-stage renal failure requiring renal replacement therapy.

Ages Eligible for Study

to 17 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Boston Children's Hospital,

Study Record Dates

2026-05