ACTIVE_NOT_RECRUITING

A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Among patients with stable ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD). Ischemia based on symptoms or stress testing may be due to coronary microvascular dysfunction in up to 40% of these patients. However, the mechanisms and optimal treatment of coronary microvascular dysfunction are unknown. Aberrant platelet activity and inflammation have been hypothesized as mechanisms of microvascular dysfunction. Investigators plan to evaluate association between platelet activity, inflammation, and coronary microvascular dysfunction in stable women referred for coronary angiography, and to identify non-invasive correlates of coronary microvascular dysfunction in these patients.

Official Title

A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction

Quick Facts

Study Start:2018-06-29
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT03537586

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 125 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult women age ≥18 years referred for coronary angiography
  2. * Stable ischemic heart disease, defined by ischemic symptoms and/or myocardial ischemia by stress testing
  3. * Administration of aspirin therapy prior to cardiac catheterization
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Nathaniel Smilowitz, MD
PRINCIPAL_INVESTIGATOR
NYU Langone Health

Study Locations (Sites)

New York University School of Medicine
New York, New York, 10016
United States

Collaborators and Investigators

Sponsor: NYU Langone Health

  • Nathaniel Smilowitz, MD, PRINCIPAL_INVESTIGATOR, NYU Langone Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-06-29
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2018-06-29
Study Completion Date2026-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Coronary Microvascular Disease
  • Ischemic Heart Disease
  • Myocardial Ischemia