Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas

Description

This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas. Cohort 1 participants will undergo an MR perfusion scan or 2-HG spectroscopy prior to surgery and intra-operatively. Cohort 2 participants will only undergo standard of care imaging and tumor acquisition. Participant participation will end at the completion of surgery and will be transitioned to standard of care follow-up.

Conditions

Brain Tumor Adult

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Study Overview

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Study Details

Study overview

This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas. Cohort 1 participants will undergo an MR perfusion scan or 2-HG spectroscopy prior to surgery and intra-operatively. Cohort 2 participants will only undergo standard of care imaging and tumor acquisition. Participant participation will end at the completion of surgery and will be transitioned to standard of care follow-up.

Assessment of Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas and Tumor Region-Specific Biomarker Correlation

Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas

Condition
Brain Tumor Adult
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

Huntsman Cancer Institute, Salt Lake City, Utah, United States, 84112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18 years
  • * Suspected glioma (grade II, III, or IV)
  • * Preoperative MR perfusion (enhancing tumors)
  • * Preoperative MR 2-HG spectroscopy (nonenhancing tumors)Patient indicated for surgical resection, standard radiation, and standard chemotherapy as a standard of care
  • * Karnofsky performance status ≥ 60
  • * Life expectancy \> 12 weeks
  • * Cohort 1: Ability to comply with study and follow-up procedures
  • * Cohort 2: Ability to comply with study procedures
  • * Prior diagnosis of intracranial glioma
  • * Other malignancy with expected need for systemic therapy within 3 years
  • * Inability to have 6000 grays of radiation to the brain
  • * Need for urgent palliative intervention for primary disease (e.g., impending herniation)
  • * Evidence of bleeding diathesis or coagulopathy
  • * History of intracerebral abscess within 6 months prior to Day 0
  • * Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study
  • * Pregnant females
  • * Subjects unable to undergo an MRI with contrast

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Utah,

Study Record Dates

2026-07