Pharmacogenomics of Asparaginase Induced Hepatotoxicity

Description

This pilot trial studies the impact of genetic information on developing liver damage caused by asparaginase in participants with newly diagnosed acute lymphoblastic leukemia. Testing saliva samples may help doctors find certain genetic markers that may predict whether participants will tolerate asparaginase, which is given as part of clinical care for acute lymphoblastic leukemia.

Conditions

Acute Lymphoblastic Leukemia

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Study Overview

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Study Details

Study overview

This pilot trial studies the impact of genetic information on developing liver damage caused by asparaginase in participants with newly diagnosed acute lymphoblastic leukemia. Testing saliva samples may help doctors find certain genetic markers that may predict whether participants will tolerate asparaginase, which is given as part of clinical care for acute lymphoblastic leukemia.

Pharmacogenomics of Age-Specific, Asparaginase-Induced Hepatotoxicity in Patients With Acute Lymphoblastic Leukemia

Pharmacogenomics of Asparaginase Induced Hepatotoxicity

Condition
Acute Lymphoblastic Leukemia
Intervention / Treatment

-

Contacts and Locations

Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States, 90033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Newly diagnosed with acute lymphoblastic leukemia (ALL) - no prior treatment for ALL
  • * Receiving asparaginase as part of the primary treatment regimen
  • * Ability to understand and the willingness to sign a written informed consent
  • * For retrospective recruitment, those who have received asparaginase between 2012 and 2017; and are current patients of University of Southern California (USC)
  • * Patients who are unable to give informed consent

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Southern California,

Houda Alachkar, Ph.D., PRINCIPAL_INVESTIGATOR, University of Southern California

Study Record Dates

2026-05-22