Dosing of Methadone for Spine Surgery

Description

This study compares two methods of dosing methadone for complex spine cases

Conditions

Pain, Postoperative

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Study Overview

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Study Details

Study overview

This study compares two methods of dosing methadone for complex spine cases

Dosing of Methadone for Spine Surgery

Dosing of Methadone for Spine Surgery

Condition
Pain, Postoperative
Intervention / Treatment

-

Contacts and Locations

Gainesville

UF Health, Gainesville, Florida, United States, 32610-3003

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients must consent to participate and sign the IRB-approved informed consent prior to beginning any study specific procedures.
  • 2. At or between the ages 18 to 75 years.
  • 3. Undergoing multilevel thoracic, thoracolumbar and/or lumbar spine surgery with instrumentation and fusion.
  • 1. Methadone or buprenorphine use.
  • 2. Morbid obesity with BMI\>40 Kg/m2.
  • 3. Chronic renal failure with creatinine\>2.0 mg/dL.
  • 4. Liver failure as determined by cirrhosis or history of fulminant hepatic failure.
  • 5. Current or historical alcohol abuse.
  • 6. Current or historical drug abuse.
  • 7. Patients with history of prolonged QTc, as defined as a QTc value \>450 ms in males and \>460 ms in females.
  • 8. Patients with ASA status IV or V.
  • 9. Surgical diagnosis including spine tumor, infection, or trauma.
  • 10. In the Principal Investigator's opinion is not a candidate for the study.
  • 11. Unwilling to sign the informed consent form.

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Christoph Seubert, MD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2025-05-09