RECRUITING

Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study adopts a strategy that has arisen from basic neuroscience research on facilitating adaptive brain plasticity and applies this to rehabilitation to improve functional recovery in peripheral nervous system injuries (including hand transplantation, hand replantation, and surgically repaired upper extremity nerve injuries). The technique involves combining behavioral training with transcranial direct current stimulation (tDCS)-a non-invasive form of brain stimulation capable of facilitating adaptive changes in brain organization.

Official Title

Harnessing Neuroplasticity to Enhance Functional Recovery in Allogeneic Hand Transplant and Heterotopic Hand Replant Recipients

Quick Facts

Study Start:2018-08-15
Study Completion:2025-06-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03610763

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Individuals whom have received a unilateral allogeneic transplantation proximal to the wrist and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).
  2. * Individuals whom have undergone a complete amputation the hand between the wrist and elbow followed by successful re-attachment and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).
  3. * Individuals whom have undergone repairs of the median, ulnar, or other related or nearby nerve(s) following complex volar forearm lacerations or other injuries between the distal wrist crease and the flexor musculotendinous junctions. Individuals must be at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).
  1. * Individuals with significant/severe brain trauma
  2. * Serious psychiatric conditions
  3. * Chronic or severe neurological conditions.
  4. * Current pregnancy
  5. * History of seizures or unexplained loss of consciousness
  6. * Metallic implants above the chest
  7. * Certain implanted medical devices.

Contacts and Locations

Study Contact

Scott H Frey, Ph.D., Ed.M.
CONTACT
573-882-4572
freylab@missouri.edu

Principal Investigator

Scott H Frey, Ph.D., Ed.M.
PRINCIPAL_INVESTIGATOR
University of Missouri-Columbia

Study Locations (Sites)

Christine Kleinert Institute for Hand & Microsurgery
Louisville, Kentucky, 40202
United States
University of Missouri
Columbia, Missouri, 65211
United States
Washington University School of Medicine
Saint Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: University of Missouri-Columbia

  • Scott H Frey, Ph.D., Ed.M., PRINCIPAL_INVESTIGATOR, University of Missouri-Columbia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-08-15
Study Completion Date2025-06-01

Study Record Updates

Study Start Date2018-08-15
Study Completion Date2025-06-01

Terms related to this study

Keywords Provided by Researchers

  • Rehabilitation Neuroscience
  • Transcranial Direct Current Stimulation
  • Rehabilitation Therapy
  • Neuroplasticity
  • Transplantation
  • Hand Therapy
  • Constraint Induced Movement Therapy
  • Peripheral Nerve Injuries
  • tDCS
  • CIMT

Additional Relevant MeSH Terms

  • Hand Transplantation
  • Peripheral Nerve Injuries
  • Neurologic Rehabilitation