RECRUITING

Management of Esophagitis Following Repair of Esophageal Atresia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to prospectively evaluate the impact of antacid therapy on esophagitis in children with repaired esophageal atresia. Recent clinical guidelines have attempted to define a systematic approach to the management of these patients with regards to minimizing and treating esophagitis (Krishnan et al 2016), however the quality of evidence supporting many of the recommendations are based on expert opinion or on limited, retrospective studies. Risk factors for esophagitis and optimal length of antacid therapy are not well defined. Through this study, we aim to identify risk factors for the presence of esophagitis in patients with repaired esophageal atresia. We hypothesize that antacid therapy improves esophagitis severity in children following esophageal repair.

Official Title

Management of Esophagitis Following Repair of Esophageal Atresia

Quick Facts

Study Start:2019-02-01
Study Completion:2025-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03619408

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Days to 17 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * All repaired esophageal atresia patients with primary esophageal anastomosis treated at Boston Children's Hospital are eligible to enroll before or at year-1 surveillance endoscopy
  1. * Patients with jejunal or colonic interpositions

Contacts and Locations

Study Contact

Michael Manfredi, MD
CONTACT
617-355-3038
michael.manfredi@childrens.harvard.edu
Jessica Yasuda, MD
CONTACT
617-355-3038
jessica.yasuda@childrens.harvard.edu

Study Locations (Sites)

Boston Children's Hospital
Boston, Massachusetts, 02115
United States
Boston Childrens Hospital
Boston, Massachusetts, 02115
United States

Collaborators and Investigators

Sponsor: Boston Children's Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-02-01
Study Completion Date2025-07

Study Record Updates

Study Start Date2019-02-01
Study Completion Date2025-07

Terms related to this study

Keywords Provided by Researchers

  • Esophageal Atresia
  • Esophagitis
  • GER
  • Gastroesopheal reflux
  • PPI

Additional Relevant MeSH Terms

  • Esophageal Atresia
  • Esophagitis