NSAIDs Stent Study

Description

This is a pilot study to (1) evaluate the effect of Ketorolac on inflammatory response and its impact on stent related symptoms in patients undergoing stent placement procedure and (2) assess feasibility of recruitment, randomization, assessment procedures and implementation of the study intervention.

Conditions

Ureteral Stent Placement, Kidney Stone

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Study Overview

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Study Details

Study overview

This is a pilot study to (1) evaluate the effect of Ketorolac on inflammatory response and its impact on stent related symptoms in patients undergoing stent placement procedure and (2) assess feasibility of recruitment, randomization, assessment procedures and implementation of the study intervention.

A Prospective, Randomized, Pilot Study of Preoperative Anti-Inflammatory Therapy for Ureteral Stent Symptoms

NSAIDs Stent Study

Condition
Ureteral Stent Placement
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Over 18 years of age and willing and able to provide informed consent
  • * Patients with renal urolithiasis planning to undergo ureteral stent placement following ureteroscopic manipulation
  • * Patients requiring a bilateral stone procedure.
  • * Patients on a chronic non-steroidal anti-inflammatory drugs (NSAIDs) including Aspirin defined as any NSAIDs use for more than fifteen days within thirty days prior to the procedure. Exception: use of daily Aspirin 81 mg is allowed.
  • * Patients on any steroid therapy.
  • * Patients with prescription anti-inflammatory drugs.
  • * Patients with gastrointestinal ulcers.
  • * Patients with ureteral obstruction or stricture unrelated to stone disease.
  • * Patients with active urinary tract infection as evidence of untreated positive urine culture obtained prior to the procedure (as part of pre-operative testing).
  • * Patients with preexisting indwelling ureteral stent
  • * Patients who are pregnant or lactating.
  • * Patients with renal or liver impairment.
  • * Patients with concurrent disease, infection, or co-morbidity that, in the judgment of the investigator, would render the patient inappropriate for enrollment.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington University School of Medicine,

Alana Desai, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2026-10