Natural History, Diagnosis, and Outcomes for Leukodystrophies

Eligibility Criteria

• * evidence by clinical exam, radiological findings, and/or testing, of an inherited leukodystrophy.
• * be able to travel to the leukodystrophy clinic (at Primary Children's Hospital, Salt Lake City, Utah);
• * be able to tolerate a general physical exam, and a neurological exam.
• * unable to be evaluated at the University of Utah Hospital or Primary Children's Hospital;
• * refusal to sign study consent form;
• * evidence or finding of another non-genetic cause of their condition;
• * Persons with known white matter disease or lesions related to: birth injury or prenatal injury, multiple sclerosis, trauma, infection, immunization, or post-infectious effects (e.g. ADEM- acute disseminated encephalomyelitis), metabolic disturbance (e.g. Central pontine myelinolysis), neoplasms, primary rheumatologic diseases (e.g. Systemic lupus erythematosis), stroke, hypoxic-ischemic injury, drug or toxin effect, seizures, or endocrine disturbance.