RECRUITING

Improving Infant Hydrocephalus Outcomes in Uganda

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative prognostic indicators of treatment response and long term outcomes.

Official Title

Improving Infant Hydrocephalus Outcomes in Uganda: Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure After ETV/CPC

Quick Facts

Study Start:2021-05-05
Study Completion:2026-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03650101

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:1 Day to 180 Days
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * Infants less than 180 days (six months) old
  2. * Symptomatic hydrocephalus characterized by abnormal rate of head growth, full anterior fontanel, ventriculomegaly
  3. * A parent or a guardian qualified by Ugandan law to give informed consent
  4. * Patients from Eastern, Central and Northern districts of Uganda, and in geographic proximity to CURE hospital will be eligible
  1. * Age greater than six months
  2. * No evidence of progressive hydrocephalus
  3. * Patients outside of the districts specified in the inclusion criteria

Contacts and Locations

Study Contact

Pei-Yi Lin, PhD
CONTACT
6179191308
Ivy.Lin@childrens.harvard.edu
Matthew Foster
CONTACT
6179192729
osp@childrens.harvard.edu

Principal Investigator

Pei-Yi Lin, PhD
PRINCIPAL_INVESTIGATOR
Boston Children's Hospital

Study Locations (Sites)

Penn State University
University Park, Pennsylvania, 16802
United States

Collaborators and Investigators

Sponsor: Boston Children's Hospital

  • Pei-Yi Lin, PhD, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-05-05
Study Completion Date2026-01

Study Record Updates

Study Start Date2021-05-05
Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

  • Hydrocephalus

Additional Relevant MeSH Terms

  • Hydrocephalus