Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Description

Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.

Conditions

Glaucoma, Primary Open Angle

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Study Overview

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Study Details

Study overview

Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.

Acute Changes in Optic Nerve Head (ONH) and Macular Blood Flow After Caffeine Consumption in Glaucoma Patients and Healthy Subjects: A Quantitative Optic Coherence Tomography Angiography (OCTA) Study

Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Condition
Glaucoma, Primary Open Angle
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Wills Eye Glaucoma Service, Philadelphia, Pennsylvania, United States, 19107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * age 18 to 90 years
  • * diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)
  • * healthy subjects with no eye disease
  • * Diseases, ophthalmic or systemic, that are likely to affect OCTA results
  • * greater than moderate cataract
  • * nystagmus
  • * inability to look at target
  • * macular degeneration other than mild drusen or pigmentary changes
  • * diabetic retinopathy
  • * neovascular glaucoma or non-glaucoma optic neuropathies
  • * current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy
  • * keratoconus, corneal ectasia, central corneal scarring
  • * rheumatologic diseases or Raynaud's phenomena
  • * pregnant and lactating women
  • * mental illness or alcohol addiction
  • * pre-existing bladder symptoms, cardiac disease or sleep disorder
  • * refractive spherical diopter greater than 5 or cylinder greater than 3
  • * possible tolerance to caffeine (drinking more than 1 cup coffee per day).

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Wills Eye,

M. Reza Razeghinejad, MD, PRINCIPAL_INVESTIGATOR, Wills Eye Hospital

Study Record Dates

2025-12-31