RECRUITING

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

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Conditions

Castration Levels of TestosteroneMetastatic Prostatic AdenocarcinomaStage IV Prostate Cancer AJCC v8Stage IVA Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.

Official Title

Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

Quick Facts

Study Start:2018-09-24
Study Completion:2031-10-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03678025

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:MALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: All patients must have a histologically or cytologically proven diagnosis of adenocarcinoma of the prostate. Patients with pure small cell carcinoma\* (SCC), sarcomatoid, or squamous cell carcinoma are not eligible. (\*morphology must be consistent with SCC; synaptophysin or chromogranin positive by immunohistochemical staining is insufficient to diagnose SCC).
  2. * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have an intact prostate. No prior local therapy for prostate adenocarcinoma is allowed (e.g., brachytherapy, high-intensity focused ultrasound \[HIFU\], cryotherapy, laser ablative therapies). Any prior therapy for benign conditions, such as obstruction, are acceptable (e.g., transurethral resection of the prostate, greenlight laser ablation, microwave ablation).
  3. * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have evidence of metastatic disease on technetium bone scan and computed tomography (CT) or magnetic resonance imaging (MRI) within 42 days prior to starting standard systemic therapy. Metastatic disease that is detected by positron emission tomography (PET) scan only (sodium fluoride \[NaF\], prostate-specific membrane antigen \[PSMA\], anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid \[FACBC\], carbon \[C\]11) but not conventional imaging (technetium \[Tc\]99 bone scan, CT or MRI) or solitary metastases by conventional imaging, must be confirmed histologically or cytologically.
  4. * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients with known brain metastases are not eligible. Brain imaging studies are not required for eligibility if the patient has no neurologic signs or symptoms suggestive of brain metastasis. If brain imaging studies are performed, they must be negative for disease.
  5. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received no more than 28 weeks of standard systemic therapy (SST). SST is defined as current National Comprehensive Cancer Network (NCCN) guidelines for metastatic prostate cancer.
  6. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not have progressed while on SST.
  7. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients with oligometastatic prostate cancer may receive metastasis directed therapy to up to four sites of disease prior to randomization.
  8. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a complete physical examination and medical history within 28 days prior to registration.
  9. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA documented prior to initiation of SST and within 28 days prior to registration. Any additional PSAs measured while receiving SST should be recorded.
  10. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone lab documented within 28 days prior to randomization. Any additional testosterone labs measured while receiving SST should be recorded as well as pretreatment initiation if available.
  11. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated stage 0, I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years.
  12. * STEP 1 REGISTRATION: SPECIMEN SUBMISSION CRITERIA: Patients must be offered the opportunity to participate in translational medicine studies and specimen banking for future studies.
  13. * STEP 1 REGISTRATION: QUALITY OF LIFE CRITERIA: Patients who can complete Patient-Reported Outcome instruments in English, Spanish or French, must participate in the quality of life studies.
  14. * STEP 1 REGISTRATION: REGULATORY CRITERIA: Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
  15. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.
  16. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have no evidence of disease progression during the 28 weeks of SST by PSA measure, bone scan and CT or MRI or symptomatic deterioration (as defined by physician discretion) within 28 days prior to randomization.
  17. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have consultation with a urologist and have surgically resectable disease regardless of definitive treatment intent or randomization.
  18. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received between 22 and 28 weeks of SST as measured from the date of first hormonal therapy or surgical castration. SST is defined by current NCCN guidelines for metastatic prostate cancer.
  19. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not be planning to receive docetaxel after randomization.
  20. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Any toxicities from SST must have resolved to =\< grade 1 (Common Terminology Criteria for Adverse Events \[CTCAE\] version 5.0) prior to randomization.
  21. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients may have received elective metastasis directed therapy to oligometastatic sites (=\< 4 sites). All treatment must be completed prior to randomization.
  22. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA performed within 28 days prior to randomization.
  23. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone \< 50 ng/dL within 28 days prior to randomization.
  24. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a Zubrod performance status of 0 ? 1 within 28 days prior to randomization.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Dana Sparks, MAT
CONTACT
2106148808
dsparks@swog.org

Principal Investigator

Brian Chapin
PRINCIPAL_INVESTIGATOR
SWOG Cancer Research Network

Study Locations (Sites)

Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234
United States
Cancer Center at Saint Joseph's
Phoenix, Arizona, 85004
United States
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054
United States
Mayo Clinic in Arizona
Scottsdale, Arizona, 85259
United States
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona, 85704
United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
United States
Community Cancer Institute
Clovis, California, 93611
United States
University Oncology Associates
Clovis, California, 93611
United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
United States
Kaiser Permanente Dublin
Dublin, California, 94568
United States
Kaiser Permanente-Fremont
Fremont, California, 94538
United States
Fresno Cancer Center
Fresno, California, 93720
United States
Kaiser Permanente-Fresno
Fresno, California, 93720
United States
UC San Diego Moores Cancer Center
La Jolla, California, 92093
United States
Tibor Rubin VA Medical Center
Long Beach, California, 90822
United States
Los Angeles County-USC Medical Center
Los Angeles, California, 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
United States
Fremont - Rideout Cancer Center
Marysville, California, 95901
United States
Kaiser Permanente-Modesto
Modesto, California, 95356
United States
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
United States
Kaiser Permanente-Oakland
Oakland, California, 94611
United States
Desert Regional Medical Center
Palm Springs, California, 92262
United States
Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304
United States
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
United States
Kaiser Permanente-Redwood City
Redwood City, California, 94063
United States
Kaiser Permanente-Richmond
Richmond, California, 94801
United States
Rohnert Park Cancer Center
Rohnert Park, California, 94928
United States
Kaiser Permanente-Roseville
Roseville, California, 95661
United States
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
United States
Kaiser Permanente Downtown Commons
Sacramento, California, 95814
United States
Mercy Cancer Center - Sacramento
Sacramento, California, 95816
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
United States
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
United States
South Sacramento Cancer Center
Sacramento, California, 95823
United States
Kaiser Permanente-San Francisco
San Francisco, California, 94115
United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
United States
Kaiser Permanente San Leandro
San Leandro, California, 94577
United States
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, 93401
United States
Kaiser San Rafael-Gallinas
San Rafael, California, 94903
United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
United States
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
United States
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
United States
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
United States
Kaiser Permanente-Stockton
Stockton, California, 95210
United States
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California, 96161
United States
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
United States
Kaiser Permanente-Vallejo
Vallejo, California, 94589
United States
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
United States
University of Colorado Hospital
Aurora, Colorado, 80045
United States
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
United States
Memorial Hospital North
Colorado Springs, Colorado, 80920
United States
Porter Adventist Hospital
Denver, Colorado, 80210
United States
Shaw Cancer Center
Edwards, Colorado, 81632
United States
Poudre Valley Hospital
Fort Collins, Colorado, 80524
United States
North Colorado Medical Center
Greeley, Colorado, 80631
United States
Littleton Adventist Hospital
Littleton, Colorado, 80122
United States
McKee Medical Center
Loveland, Colorado, 80539
United States
Parker Adventist Hospital
Parker, Colorado, 80138
United States
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
United States
Yale University
New Haven, Connecticut, 06520
United States
Stamford Hospital/Bennett Cancer Center
Stamford, Connecticut, 06904
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
United States
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven, Connecticut, 06516
United States
Helen F Graham Cancer Center
Newark, Delaware, 19713
United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
United States
MedStar Georgetown University Hospital
Washington, District of Columbia, 20007
United States
MedStar Washington Hospital Center
Washington, District of Columbia, 20010
United States
George Washington University Medical Center
Washington, District of Columbia, 20037
United States
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida, 33180
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442
United States
Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207
United States
Mount Sinai Medical Center
Miami Beach, Florida, 33140
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, 33176
United States
Orlando Health Cancer Institute
Orlando, Florida, 32806
United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, 33324
United States
Grady Health System
Atlanta, Georgia, 30303
United States
Emory University Hospital Midtown
Atlanta, Georgia, 30308
United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
United States
Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342
United States
Augusta University Medical Center
Augusta, Georgia, 30912
United States
Atlanta VA Medical Center
Decatur, Georgia, 30033
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
United States
Rush - Copley Medical Center
Aurora, Illinois, 60504
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
United States
Illinois CancerCare-Canton
Canton, Illinois, 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
United States
Northwestern University
Chicago, Illinois, 60611
United States
Rush University Medical Center
Chicago, Illinois, 60612
United States
University of Illinois
Chicago, Illinois, 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
United States
Decatur Memorial Hospital
Decatur, Illinois, 62526
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
United States
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
United States
Loyola University Medical Center
Maywood, Illinois, 60153
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
United States
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
United States
Illinois CancerCare-Peru
Peru, Illinois, 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
United States
Southwest Illinois Health Services LLP
Swansea, Illinois, 62226
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
United States
Reid Health
Richmond, Indiana, 47374
United States
McFarland Clinic - Ames
Ames, Iowa, 50010
United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
United States
University of Kansas Cancer Center
Kansas City, Kansas, 66160
United States
Olathe Health Cancer Center
Olathe, Kansas, 66061
United States
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205
United States
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
United States
Saint Joseph Hospital East
Lexington, Kentucky, 40509
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202
United States
East Jefferson General Hospital
Metairie, Louisiana, 70006
United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic
Metairie, Louisiana, 70006
United States
MaineHealth Coastal Cancer Treatment Center
Bath, Maine, 04530
United States
Lafayette Family Cancer Center-EMMC
Brewer, Maine, 04412
United States
Maine Medical Center-Bramhall Campus
Portland, Maine, 04102
United States
MaineHealth Cancer Care Center of York County
Sanford, Maine, 04073
United States
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford, Maine, 04073
United States
Maine Medical Center- Scarborough Campus
Scarborough, Maine, 04074
United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
United States
Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805
United States
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109
United States
Saint Joseph Mercy Brighton
Brighton, Michigan, 48114
United States
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, 48183
United States
Saint Joseph Mercy Canton
Canton, Michigan, 48188
United States
Saint Joseph Mercy Chelsea
Chelsea, Michigan, 48118
United States
GenesisCare USA - Clarkston
Clarkston, Michigan, 48346
United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, 48038
United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201
United States
Henry Ford Hospital
Detroit, Michigan, 48202
United States
GenesisCare USA - Farmington Hills
Farmington Hills, Michigan, 48334
United States
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, 49503
United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
United States
Sparrow Hospital
Lansing, Michigan, 48912
United States
GenesisCare USA - Macomb
Macomb, Michigan, 48044
United States
GenesisCare USA - Madison Heights
Madison Heights, Michigan, 48071
United States
21st Century Oncology-Pontiac
Pontiac, Michigan, 48341
United States
Ascension Saint Mary's Hospital
Saginaw, Michigan, 48601
United States
Munson Medical Center
Traverse City, Michigan, 49684
United States
GenesisCare USA - Troy
Troy, Michigan, 48098
United States
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322
United States
Mercy Hospital
Coon Rapids, Minnesota, 55433
United States
Fairview Southdale Hospital
Edina, Minnesota, 55435
United States
Unity Hospital
Fridley, Minnesota, 55432
United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
United States
Health Partners Inc
Minneapolis, Minnesota, 55454
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
United States
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
Southeast Cancer Center
Cape Girardeau, Missouri, 63703
United States
University of Missouri - Ellis Fischel
Columbia, Missouri, 65212
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141
United States
Freeman Health System
Joplin, Missouri, 64804
United States
University of Kansas Cancer Center - North
Kansas City, Missouri, 64154
United States
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, 65401
United States
Washington University School of Medicine
Saint Louis, Missouri, 63110
United States
Siteman Cancer Center-South County
Saint Louis, Missouri, 63129
United States
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
United States
Siteman Cancer Center at Christian Hospital
Saint Louis, Missouri, 63136
United States
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
United States
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri, 63376
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
United States
Mercy Hospital Springfield
Springfield, Missouri, 65804
United States
CoxHealth South Hospital
Springfield, Missouri, 65807
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Bozeman Deaconess Hospital
Bozeman, Montana, 59715
United States
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, 59701
United States
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, 59405
United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901
United States
Nebraska Medicine-Bellevue
Bellevue, Nebraska, 68123
United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska, 68118
United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198
United States
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada, 89052
United States
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106
United States
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada, 89128
United States
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada, 89144
United States
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148
United States
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, 89169
United States
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire, 03301
United States
Wentworth-Douglass Hospital
Dover, New Hampshire, 03820
United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
United States
Elliot Hospital
Manchester, New Hampshire, 03103
United States
Solinsky Center for Cancer Care
Manchester, New Hampshire, 03103
United States
Hackensack University Medical Center
Hackensack, New Jersey, 07601
United States
Holy Name Hospital
Teaneck, New Jersey, 07666
United States
Albany Medical Center
Albany, New York, 12208
United States
Montefiore Medical Center-Einstein Campus
Bronx, New York, 10461
United States
Montefiore Medical Center - Moses Campus
Bronx, New York, 10467
United States
James J Peters VA Medical Center
Bronx, New York, 10468
United States
Roswell Park Cancer Institute
Buffalo, New York, 14263
United States
Noyes Memorial Hospital/Myers Cancer Center
Dansville, New York, 14437
United States
Glens Falls Hospital
Glens Falls, New York, 12801
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
United States
NYP/Weill Cornell Medical Center
New York, New York, 10065
United States
Upstate Cancer Center Radiation Oncology at Oneida
Oneida, New York, 13421
United States
Upstate Cancer Center Radiation Oncology at Oswego
Oswego, New York, 13126
United States
Highland Hospital
Rochester, New York, 14620
United States
University of Rochester
Rochester, New York, 14642
United States
Stony Brook University Medical Center
Stony Brook, New York, 11794
United States
State University of New York Upstate Medical University
Syracuse, New York, 13210
United States
Atrium Health Stanly/LCI-Albemarle
Albemarle, North Carolina, 28002
United States
Mission Hospital
Asheville, North Carolina, 28801
United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
United States
Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina, 28210
United States
Atrium Health University City/LCI-University
Charlotte, North Carolina, 28262
United States
Levine Cancer Institute-Ballantyne
Charlotte, North Carolina, 28277
United States
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, 28025
United States
Levine Cancer Institute-Gaston
Gastonia, North Carolina, 28054
United States
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, 28791
United States
Atrium Health Union/LCI-Union
Monroe, North Carolina, 28112
United States
CarolinaEast Medical Center
New Bern, North Carolina, 28561
United States
Cleveland Clinic Mercy Hospital
Canton, Ohio, 44708
United States
Miami Valley Hospital South
Centerville, Ohio, 45459
United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219
United States
MetroHealth Medical Center
Cleveland, Ohio, 44109
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
United States
Miami Valley Hospital North
Dayton, Ohio, 45415
United States
Greater Dayton Cancer Center
Kettering, Ohio, 45409
United States
Kettering Medical Center
Kettering, Ohio, 45429
United States
ProMedica Flower Hospital
Sylvania, Ohio, 43560
United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
United States
University of Toledo
Toledo, Ohio, 43614
United States
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030
United States
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, 97210
United States
Oregon Health and Science University
Portland, Oregon, 97239
United States
Chambersburg Hospital
Chambersburg, Pennsylvania, 17201
United States
Geisinger Medical Center
Danville, Pennsylvania, 17822
United States
Ephrata Cancer Center
Ephrata, Pennsylvania, 17522
United States
Adams Cancer Center
Gettysburg, Pennsylvania, 17325
United States
Sechler Family Cancer Center
Lebanon, Pennsylvania, 17042
United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
United States
Temple University Hospital
Philadelphia, Pennsylvania, 19140
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232
United States
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, 15232
United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
United States
WellSpan Health-York Cancer Center
York, Pennsylvania, 17403
United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
United States
Saint Francis Cancer Center
Greenville, South Carolina, 29607
United States
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
United States
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
United States
Carolina Regional Cancer Center
Myrtle Beach, South Carolina, 29577
United States
Rock Hill Radiation Therapy Center
Rock Hill, South Carolina, 29730
United States
Levine Cancer Institute-Rock Hill
Rock Hill, South Carolina, 29732
United States
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
United States
MD Anderson in The Woodlands
Conroe, Texas, 77384
United States
Parkland Memorial Hospital
Dallas, Texas, 75235
United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas, 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas, 76104
United States
Lyndon Baines Johnson General Hospital
Houston, Texas, 77026-1967
United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
United States
Ben Taub General Hospital
Houston, Texas, 77030
United States
Houston Methodist Hospital
Houston, Texas, 77030
United States
M D Anderson Cancer Center
Houston, Texas, 77030
United States
Michael E DeBakey VA Medical Center
Houston, Texas, 77030
United States
MD Anderson West Houston
Houston, Texas, 77079
United States
MD Anderson League City
League City, Texas, 77573
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, 75080
United States
Audie L Murphy VA Hospital
San Antonio, Texas, 78229
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
United States
MD Anderson in Sugar Land
Sugar Land, Texas, 77478
United States
Scott and White Memorial Hospital
Temple, Texas, 76508
United States
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork, Utah, 84003
United States
Sandra L Maxwell Cancer Center
Cedar City, Utah, 84720
United States
Logan Regional Hospital
Logan, Utah, 84321
United States
Intermountain Medical Center
Murray, Utah, 84107
United States
McKay-Dee Hospital Center
Ogden, Utah, 84403
United States
Utah Valley Regional Medical Center
Provo, Utah, 84604
United States
Riverton Hospital
Riverton, Utah, 84065
United States
Saint George Regional Medical Center
Saint George, Utah, 84770
United States
University of Utah Sugarhouse Health Center
Salt Lake City, Utah, 84106
United States
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah, 84106
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
United States
LDS Hospital
Salt Lake City, Utah, 84143
United States
George E Wahlen Department of Veterans Affairs Medical Center
Salt Lake City, Utah, 84148
United States
Central Vermont Medical Center/National Life Cancer Treatment
Berlin, Vermont, 05602
United States
University of Vermont Medical Center
Burlington, Vermont, 05401
United States
Bon Secours Saint Francis Medical Center
Midlothian, Virginia, 23114
United States
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, Virginia, 23230
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, 23235
United States
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
United States
VCU Community Memorial Health Center
South Hill, Virginia, 23970
United States
FHCC Overlake
Bellevue, Washington, 98004
United States
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland, Washington, 98034
United States
FHCC South Lake Union
Seattle, Washington, 98109
United States
FHCC at Northwest Hospital
Seattle, Washington, 98133
United States
University of Washington Medical Center - Montlake
Seattle, Washington, 98195
United States
Legacy Salmon Creek Hospital
Vancouver, Washington, 98686
United States
West Virginia University Healthcare
Morgantown, West Virginia, 26506
United States
Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
United States
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, 54601
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051
United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
United States
Zablocki Veterans Administration Medical Center
Milwaukee, Wisconsin, 53295
United States
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, 54548
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin, 53154
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
United States
Ascension Saint Michael's Hospital
Stevens Point, Wisconsin, 54481
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
United States
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095
United States
Diagnostic and Treatment Center
Weston, Wisconsin, 54476
United States
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, 54494
United States

Collaborators and Investigators

Sponsor: SWOG Cancer Research Network

  • Brian Chapin, PRINCIPAL_INVESTIGATOR, SWOG Cancer Research Network

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-09-24
Study Completion Date2031-10-01

Study Record Updates

Study Start Date2018-09-24
Study Completion Date2031-10-01

Terms related to this study

Additional Relevant MeSH Terms

  • Castration Levels of Testosterone
  • Metastatic Prostatic Adenocarcinoma
  • Stage IV Prostate Cancer AJCC v8
  • Stage IVA Prostate Cancer AJCC v8
  • Stage IVB Prostate Cancer AJCC v8