RECRUITING

Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer \[11C\]PBR-28 or \[11C\]ER176.

Official Title

Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

Quick Facts

Study Start:2017-05-01
Study Completion:2028-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03705715

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Must be between 18-80 years old
  2. * Males or females
  3. * Must be right handed
  4. * Must be able to sit unaccompanied for long periods of time with little body movement
  5. * Must be illicit drug free at time of scanning as appropriate (UDS negative),
  6. * Must be either healthy (without medical, neurological, psychiatric illness) or have a diagnosis of a neuropsychiatric syndrome (mood disorder, chronic pain syndrome, dementias, traumatic brain injury, substance/alcohol use disorder).
  7. * Healthy Control volunteers must be medication free (≥ 14 days)
  8. * Illicit drug free at time of scanning (verified by negative urine drug screen)
  1. * Must not be a smoker.
  2. * Females must not be pregnant or nursing.
  3. * Must not suffer from claustrophobia
  4. * Must not meet exclusion criteria for MRI scanning (i.e. non-fixed magnetisable objects)
  5. * Must not be PBR-28 low affinity binder (or using the \[11C\]ER176 study radiotracer)
  6. * Healthy control volunteers must not have on-going, chronic, or relapsing/remitting medical, psychiatric (absence of both DSM-IV Axis I and/or Axis II disorders), or neurological illness as determined by combination of history, medical record, and/or examination.

Contacts and Locations

Study Contact

Alan Prossin, MBBS
CONTACT
713-486-2836
alan.prossin@uth.tmc.edu

Principal Investigator

Alan Prossin, MBBS
PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston

Study Locations (Sites)

BBSB at UTHealth
Houston, Texas, 77054
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center, Houston

  • Alan Prossin, MBBS, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center, Houston

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2017-05-01
Study Completion Date2028-08

Study Record Updates

Study Start Date2017-05-01
Study Completion Date2028-08

Terms related to this study

Keywords Provided by Researchers

  • Microglial activation
  • Immune activation
  • PET neuroimaging

Additional Relevant MeSH Terms

  • Neuropsychiatric Syndromes