Measurement of the Partial Pressure of Oxygen in Cutaneous Tumors Using Electron Paramagnetic Resonance (EPR) Oximetry

Description

This protocol will take measurements of a variety of tumors involving the skin in order to assess changes in tumor oxygen from hyperoxygenation therapy and standard cancer-directed treatments, to demonstrate the clinical feasibility of using in vivo Electron Paramagnetic Resonance (EPR) Oximetry to obtain clinically useful measurements of tumor oxygen levels from cancer patients.

Conditions

Skin Lesion, Skin Cancer, Skin Melanoma, Tumor Skin

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Study Overview

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Study Details

Study overview

This protocol will take measurements of a variety of tumors involving the skin in order to assess changes in tumor oxygen from hyperoxygenation therapy and standard cancer-directed treatments, to demonstrate the clinical feasibility of using in vivo Electron Paramagnetic Resonance (EPR) Oximetry to obtain clinically useful measurements of tumor oxygen levels from cancer patients.

Measurement of the Partial Pressure of Oxygen in Cutaneous Tumors Using Electron Paramagnetic Resonance (EPR) Oximetry

Measurement of the Partial Pressure of Oxygen in Cutaneous Tumors Using Electron Paramagnetic Resonance (EPR) Oximetry

Condition
Skin Lesion
Intervention / Treatment

-

Contacts and Locations

Morgantown

Todd Tenenholz, Morgantown, West Virginia, United States, 26506

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Pathology-proven (histology or cytology) malignancy of any histology and site of origin
  • * Visible tumor (primary or metastasis) involving the skin of at least 6 mm in diameter
  • * Negative serum or urine pregnancy test within 72 hours prior to registration for women of childbearing potential
  • * Implanted electric, magnetic or mechanically activated devices like a pacemaker, defibrillator, nerve stimulator, cochlear implant or portable infusion pump. Also individuals who have any non-MRI compatible implants
  • * Individuals who have a ferromagnetic foreign body located in their body
  • * Prior adverse reaction to a charcoal product (e.g., a local hypersensitive response from a black tattoo or from ingestion of activated charcoal)
  • * Prior adverse reaction to gum Arabic, which is an ingredient in the India ink
  • * Prior allergic reaction to medical adhesives
  • * Psychiatric illness/social situations that would limit compliance with study requirements
  • * Pregnant or lactating women. There is no known harm to the woman or her fetus from participating; this is precautionary only

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

West Virginia University,

Todd Tenenholz, MD, PRINCIPAL_INVESTIGATOR, West Virginia University

Study Record Dates

2024-07