A Study Utilizing Escitalopram in Glioma Patients

Description

This pilot study will include grade IV glioma patients treated with SSRIs during approximately a 17 week study period. Changes in cognition and evaluation of psychosocial factors from baseline to after 17 weeks of treatment with SSRI study drug will be calculated.

Conditions

Glioma of Brain, Glioma

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Study Overview

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Study Details

Study overview

This pilot study will include grade IV glioma patients treated with SSRIs during approximately a 17 week study period. Changes in cognition and evaluation of psychosocial factors from baseline to after 17 weeks of treatment with SSRI study drug will be calculated.

A Pilot Study Utilizing Escitalopram to Address Cognitive Dysfunction in Glioma Patients

A Study Utilizing Escitalopram in Glioma Patients

Condition
Glioma of Brain
Intervention / Treatment

-

Contacts and Locations

Omaha

University of Nebraska Medical Center, Omaha, Nebraska, United States, 68198

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient with pathologically proven diagnosis of Grade IV glioma
  • * Patients planning to receive chemotherapy and/or radiation for newly diagnosed disease
  • * Performance status ECOG 0-2 or equivalent
  • * Patients must be age ≥19 years
  • * Life expectancy greater than 6 months
  • * Written informed consent to participate in the study.
  • * Hemifield defects (as this obscures visual field necessary to participate in all tests)
  • * Inability to undergo MRI
  • * Severe renal impairment defined as GFR\<30 mL/minute
  • * Screen positive for depression or anxiety
  • * Already taking an anti-depressant (SSRI or NSRI)
  • * Have problems tolerating past treatment with SSRI or NSRIs
  • * Females of childbearing potential must have a negative urine pregnancy test at the study enrollment.
  • * Female patients must be either postmenopausal, free from menses for ≥2 years, surgically sterilized, or willing to use two adequate barrier forms of contraception

Ages Eligible for Study

19 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Nebraska,

Nicole A Shonka, MD, PRINCIPAL_INVESTIGATOR, University of Nebraska

Study Record Dates

2025-08