Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * With life time risk of 30% or higher, based on Polygenic Risk Score that integrates genetic and non-genetic factors OR
- * 5-years risk ≥ 6% for women 40-64 OR
- * 5-years risk ≥ 6% for women 65+ AND breast density C or D AND a lifetime risk \>= 20% (BCSC+PRS LTR or Tyrer-Cuzick LTR) OR
- * Patients with history of chest wall radiation received before age 35. OR
- * To promote health equity, women of African Ancestry \< 45 years with at least one 1st or 2nd degree relative with breast or ovarian cancer are eligible because PRS Scores are not currently reported for AA women.
- * Must be at least 25 years old.
- * Willing to travel to participating site for imaging studies as well as any necessary follow-up procedures.
- * Be able to give informed consent.
- * Patients with prior history of breast or ovarian cancer are eligible if they have completed all active treatments and are cancer free for two years.
- * Undergoing active cancer treatment at the time of enrollment.
- * Current pregnancy or plans for pregnancy within two years of enrollment.
- * Presence of a pacemaker or any other metallic foreign object in their body that interferes with an MRI.
- * Breast surgery within two weeks of study entry.
- * Women with history of bilateral mastectomy are not eligible
- * History of kidney disease or abnormal kidney function.
- * History of dye allergy unless it can be mediated with antihistamines and/or steroids
- * Women can be taking hormone replacement therapy, tamoxifen, raloxifene, aromatase inhibitors, Parp Inhibitors as adjuvant therapy or participating in a chemoprevention trial.
Ages Eligible for Study
25 Years to
Sexes Eligible for Study
FEMALE
Accepts Healthy Volunteers
Yes