COMPLETED

Neuromodulation for Exercise Adherence

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Lack of adherence to an exercise program is a major problem for older Veterans. Several fall prevention programs fail in the home setting due to lack of adherence. Exercise adherence is dependent on brain function among other factors. Magnetic stimulation of the front part of the brain improves brain function necessary for planning and following-through. The investigators propose a three-phase study in 106 sedentary older Veterans. Everyone will be trained on use of the exergame, Nintendo Wii-Fit, that the investigators' team has found beneficial in improving balance and gait. They will be asked to exercise using Wii-Fit at home for 45 minutes daily five days/week for 12-weeks. Those that exercise less than recommended dose and those that exercise adequately but have low executive function will receive either real or sham magnetic stimulation to the front part of their brain over ten sessions paired with exercise training. All subjects will further complete 24-weeks of Wii-Fit home exercises. Adherence, executive function, balance and gait, self-efficacy, delay discounting, and falls will be measured periodically.

Official Title

Neuromodulation for Exercise Adherence in Older Veterans

Quick Facts

Study Start:2019-04-01
Study Completion:2025-05-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT03733041

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Sedentary Community Dwelling Veterans age 60 years
  2. * Have TV at home
  3. * Subjects reporting spending long periods of time in sedentary behavior by answering affirmatively to the question: 'For most days, do you feel you sit for too long (6-8 hours or more a day)?
  4. * Some examples might include when watching TV, working at the computer / laptop or when doing sitting-based hobbies such as reading and sewing' will be included
  1. * Those that participate in regular physical activity for at least 30 minutes five or more days of the week
  2. * Use of wheel chair for mobility
  3. * Cognitive impairment \[Montreal Cognitive Assessment (MoCA \< 26)\]
  4. * Weight 325 lbs. (weight restriction of the Wii-Board)
  5. * Absolute contraindications to exercise per The American College of Sports Medicine guidelines
  6. * Those with medical conditions that in the opinion of the study physician are likely to compromise safe participation
  7. * Taking medications known to increase risk of seizures from 2012 Beers criteria such as bupropion, chlorpromazine, clozapine.
  8. * Taking other medications known to increase risk of seizures such as tricyclic antidepressants.
  9. * Taking ototoxic medications: Aminoglycosides, CisplatinHistory of seizures/ seizures in first degree relatives
  10. * Those with implanted device
  11. * History of stroke, aneurysm, or cranial neurosurgery
  12. * History of bipolar disorder
  13. * History of abnormal electroencephalogram (EEG)

Contacts and Locations

Principal Investigator

Kalpana P Padala, MD MS
PRINCIPAL_INVESTIGATOR
Central Arkansas Veterans Healthcare System , Little Rock, AR

Study Locations (Sites)

Central Arkansas Veterans Healthcare System , Little Rock, AR
Little Rock, Arkansas, 72205
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Kalpana P Padala, MD MS, PRINCIPAL_INVESTIGATOR, Central Arkansas Veterans Healthcare System , Little Rock, AR

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-04-01
Study Completion Date2025-05-31

Study Record Updates

Study Start Date2019-04-01
Study Completion Date2025-05-31

Terms related to this study

Keywords Provided by Researchers

  • exercise adherence
  • Older veterans
  • home based exercise

Additional Relevant MeSH Terms

  • Executive Dysfunction
  • Poor Exercise Adherence