Collagen Cross-linking in Keratoconus

Description

Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.

Conditions

Keratoconus

Study Overview

Study Details

Study overview

Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.

Clinical Trial of Laser Custom Corneal Collagen Cross-Linking in Keratoconus

Collagen Cross-linking in Keratoconus

Condition
Keratoconus
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Health & Science University, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of keratoconus
  • * Minimum corneal thickness of 410 microns
  • * Inability to maintain fixation for OCT imaging
  • * Inability to commit to required study visits
  • * Inability to give informed consent
  • * Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery
  • * Mature cataracts if found to limit visual potential to worse than 20/40

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Oregon Health and Science University,

David Huang, MD, PhD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2025-12