RECRUITING

Collagen Cross-linking in Keratoconus

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.

Official Title

Clinical Trial of Laser Custom Corneal Collagen Cross-Linking in Keratoconus

Quick Facts

Study Start:2018-06-20
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03760432

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of keratoconus
  2. * Minimum corneal thickness of 410 microns
  1. * Inability to maintain fixation for OCT imaging
  2. * Inability to commit to required study visits
  3. * Inability to give informed consent
  4. * Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery
  5. * Mature cataracts if found to limit visual potential to worse than 20/40

Contacts and Locations

Study Contact

Denzil Romfh, OD
CONTACT
503-494-4351
romfhd@ohsu.edu
Humberto Martinez, COT
CONTACT
503-494-7712
martinhu@ohsu.edu

Principal Investigator

David Huang, MD, PhD
PRINCIPAL_INVESTIGATOR
Oregon Health and Science University

Study Locations (Sites)

Oregon Health & Science University
Portland, Oregon, 97239
United States

Collaborators and Investigators

Sponsor: Oregon Health and Science University

  • David Huang, MD, PhD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-06-20
Study Completion Date2025-12

Study Record Updates

Study Start Date2018-06-20
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • Keratoconus (KCN)
  • Optical Coherence Tomography (OCT)
  • Collagen Cross-linking (CXL)

Additional Relevant MeSH Terms

  • Keratoconus