A Center Based Study of Pivotal Response Treatment for Preschoolers with Autism

Description

The purpose of this study is to examine the effectiveness of pivotal response training (PRT) in an intensive center-based environment to treat social communication deficits in children with autism spectrum disorder (ASD).

Conditions

Autism Spectrum Disorder, Autism

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Study Overview

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Study Details

Study overview

The purpose of this study is to examine the effectiveness of pivotal response training (PRT) in an intensive center-based environment to treat social communication deficits in children with autism spectrum disorder (ASD).

A Center Based Randomized Controlled Trial of Pivotal Response Treatment for Preschoolers with Autism

A Center Based Study of Pivotal Response Treatment for Preschoolers with Autism

Condition
Autism Spectrum Disorder
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford University School of Medicine, Stanford, California, United States, 94305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of Autism Spectrum Disorder (ASD) based on clinical interview and Diagnostic and Statistical Manual, 5th edition (DSM-5) and confirmed using the Autism Diagnostic Interview Revised (ADI-R) and Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) or Childhood Autism Rating Scale (CARS-2); Diagnostic and Statistical Manual, 5th edition (DSM-5), and expert clinical opinion
  • * Boys and girls between 2 years and 3 years and 11 months
  • * Ability to participate in the testing procedures to the extent that valid standard scores can be obtained
  • * Stable treatment (e.g., applied behavior analysis (ABA), speech therapy, psychotropic medication(s) or biomedical intervention(s) for at least 1 month prior to baseline measurements with no anticipated changes during study participation
  • * Developmentally delayed with Mullen Scales of Early Learning (MSEL) or Developmental Profile (DP-4) composite score below 85 (1 Standard Deviation below the mean)
  • * Availability of at least one English-speaking parent who can consistently participate in parent training and research measures.
  • * Current or lifetime diagnosis of severe psychiatric disorder (e.g., bipolar disorder, etc.)
  • * Presence of active medical problem (e.g., unstable seizure disorder or heart disease)
  • * Child primary language other than English
  • * Previous adequate trial of Pivotal Response Treatment
  • * More than 15 hours per week of in-home applied behavior analysis (ABA).

Ages Eligible for Study

2 Years to 3 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Antonio Y. Hardan, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2025-12