Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Description

The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems of the brain using fMRI.

Conditions

ADHD, Attention Deficit Hyperactivity Disorder

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Study Overview

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Study Details

Study overview

The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems of the brain using fMRI.

Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Condition
ADHD
Intervention / Treatment

-

Contacts and Locations

New York

Icahn School of Medicine at Mount Sinai, New York, New York, United States, 10029

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Pre-pubertal (e.g. Tanner stage 1 or 2)
  • * Age 7-12 inclusive
  • * Signed consent/assent
  • * Parent communicates sufficiently in English to provide informed consent and complete assessment instruments;
  • * ADHD as determined by computerized DISC (C-DISC) parent interview
  • * ADHD-Rating Scale-5 total score (interview with parent )
  • * SNAP ADHD total score (teacher) of 1.5 SD \> age/sex norms
  • * CD or severe ODD: CD or ODD + 2 symptoms of CD on C-DISC
  • * SNAP ODD/CD subscale (parent and teacher) 1.5 SD \> age/sex norms
  • * Major neurological/medical illness
  • * History of head injury
  • * Fetal exposure to alcohol/drugs
  • * Diagnosis of major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, generalized anxiety, social phobia, Tourette's Disorder, PTSD, autism spectrum disorder)
  • * Current suicidal ideation or past history of suicide attempt
  • * Wechsler Abbreviated Scale of Intelligence (WASI)75 score \<75
  • * Prior or current treatment with stimulants (prior or current treatment with non-stimulants is permitted, but participants must be off medication for 2 weeks at baseline)
  • * Current or past alcohol/drug use (DISC interview; urine toxicology)
  • * Psychological or medical condition which precludes being in the scanner (e.g., claustrophobia, morbid obesity)
  • * Metal in the body that cannot be removed (e.g., braces, metal plate)
  • * Visual disturbances that may impair task performance
  • * Precocious puberty (e.g. Tanner stage \>2) or pregnancy
  • * History of SUD in a 1st degree relative is permitted, and is expected in \~1/2 of the subjects
  • * Ongoing psychosocial treatment is allowed but should not be initiated during the study

Ages Eligible for Study

7 Years to 12 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Icahn School of Medicine at Mount Sinai,

Jeffrey Newcorn, MD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Iliyan Ivanov, MD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Study Record Dates

2025-09-25