Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for children with SCA. The primary objective of the study is to evaluate whether a pharmacokinetics-based starting hydroxyurea dose thieves superior fetal hemoglobin response to to standard weight-based initial dosing. Patients will be recruited from the pediatric sickle cell clinic at Cincinnati Children's Hospital Medical Center and from additional pediatric sickle cell centers within the United States.
Sickle Cell Disease, Sickle Cell Anemia
Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for children with SCA. The primary objective of the study is to evaluate whether a pharmacokinetics-based starting hydroxyurea dose thieves superior fetal hemoglobin response to to standard weight-based initial dosing. Patients will be recruited from the pediatric sickle cell clinic at Cincinnati Children's Hospital Medical Center and from additional pediatric sickle cell centers within the United States.
Hydroxyurea Optimization Through Precision Study
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Phoenix Children's Hospital, Phoenix, Arizona, United States, 85016
Children's Healthcare of Atlanta, Atlanta, Georgia, United States, 30342
Children's Hospital of Illinois, Peoria, Illinois, United States, 61637
Carle Foundation Hospital, Urbana, Illinois, United States, 61801
Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, United States, 46202
Indiana Hemophilia & Thrombosis Center, Inc. (IHTC), Indianapolis, Indiana, United States, 46260
Boston Children's Hospital, Boston, Massachusetts, United States, 02215
Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States, 55404
Cohen Children's Medical Center/Northwell Health, New Hyde Park, New York, United States, 11040
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
6 Months to 21 Years
ALL
No
Children's Hospital Medical Center, Cincinnati,
Patrick Niss, MD, PRINCIPAL_INVESTIGATOR, Lifespan
2023-12-31