Genetic and Epigenetic Basis of Chronic Wounds

Description

This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.

Conditions

Chronic Wounds

Study Overview

Study Details

Study overview

This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.

Genetic and Epigenetic Basis of Chronic Wounds

Genetic and Epigenetic Basis of Chronic Wounds

Condition
Chronic Wounds
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

UPMC Wound Care Centers, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18 years
  • * Willing to comply with protocol instructions, including all study visits and study activities.
  • * Chronic wounds (\> than four weeks since onset)
  • * Clinically diagnosed diabetic or non-diabetic ulcer.
  • * For patients with multiple wounds, the largest wound will be used for the study.
  • * Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)
  • * Pregnant females (self-declared) or lactating
  • * Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications)
  • * Prisoners

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Chandan K Sen, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2028-12-31