RECRUITING

Genetic and Epigenetic Basis of Chronic Wounds

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.

Official Title

Genetic and Epigenetic Basis of Chronic Wounds

Quick Facts

Study Start:2018-12-04
Study Completion:2028-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03793062

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age ≥ 18 years
  2. * Willing to comply with protocol instructions, including all study visits and study activities.
  3. * Chronic wounds (\> than four weeks since onset)
  4. * Clinically diagnosed diabetic or non-diabetic ulcer.
  5. * For patients with multiple wounds, the largest wound will be used for the study.
  1. * Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)
  2. * Pregnant females (self-declared) or lactating
  3. * Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications)
  4. * Prisoners

Contacts and Locations

Study Contact

Kiyan Shadmani, MPH
CONTACT
234-380-9436
kiyanshadmani@pitt.edu
Sashwati Roy, PhD
CONTACT
412-648-8297
sar453@pitt.edu

Principal Investigator

Chandan K Sen, PhD
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

UPMC Wound Care Centers
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Chandan K Sen, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-12-04
Study Completion Date2028-12-31

Study Record Updates

Study Start Date2018-12-04
Study Completion Date2028-12-31

Terms related to this study

Keywords Provided by Researchers

  • genome
  • epigenome
  • chronic wounds
  • genetics
  • socioeconomic

Additional Relevant MeSH Terms

  • Chronic Wounds