Mechanisms of Pregnancy Vascular Adaptations

Description

The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.

Conditions

Pre-Eclampsia, Vascular Diseases

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Study Overview

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Study Details

Study overview

The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.

Angiotensin 2 Receptor (AT2R) Expression/Activation in Endothelial Cells in Preeclampsia

Mechanisms of Pregnancy Vascular Adaptations

Condition
Pre-Eclampsia
Intervention / Treatment

-

Contacts and Locations

Madison

UnityPoint Health-Meriter Hospital, Madison, Wisconsin, United States, 53715

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * female
  • * Minimum age: 18
  • * Maximum age: 40
  • * Singleton births
  • * Minimum gestational age at consent: 28 weeks, 0 days
  • * Maximum gestational age at consent: 41 weeks, 0 days
  • * Undergoing caesarean section, either planned or otherwise with or without trial of labor
  • * Preexisting hypertension treated by antihypertensive agents during the prenatal period. This will not include treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
  • * Any major fetal structural anomalies or aneuploidies
  • * Preexisting conditions like pre-gestational type I or type II diabetes mellitus, pre-pregnancy kidney disease with increased serum creatinine above 1.2 mg/dL, or other underlying blood vessel problems like systemic lupus erythematosus or other autoimmune conditions with evidence of pre-pregnancy proteinuria or hypertension.
  • * Undergoing cesarean section for placental abruption or bleeding complications.
  • * Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Wisconsin, Madison,

Sathish Kumar, PhD, PRINCIPAL_INVESTIGATOR, University of Wisconsin, Madison

Study Record Dates

2027-04