Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Description

Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post-op NSAID use. This study sets out to determine the effect of post-op toradol use in addition to opioids compared to solely opioids in patients undergoing prophylactic nailing of the femur.

Conditions

Bone Metastases, Lymphoma, Multiple Myeloma, Opioid Use, Pain

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Study Overview

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Study Details

Study overview

Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post-op NSAID use. This study sets out to determine the effect of post-op toradol use in addition to opioids compared to solely opioids in patients undergoing prophylactic nailing of the femur.

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Condition
Bone Metastases
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Saint Louis University, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Femoral Shaft or Neck bone lesion
  • 2. 18 years old or greater
  • 3. Plan to undergo prophylactic intramedullary nailing of one femur
  • 1. Concurrent pathologic fracture
  • 2. History of advanced renal impairment (eGFR\<30mL/min)
  • 3. History of Peptic Ulcer Disease with bleeding or requiring hospitalization
  • 4. History of NSAID or aspirin allergy
  • 5. Concurrent chemotherapy regimen that prevents NSAID use
  • 6. History of liver disease that precludes use of toradol
  • 7. History of heart failure or cardiovascular disease that precludes toradol usage
  • 8. Pregnancy
  • 9. History of narcotic allergy resulting in anaphylaxis
  • 10. Patients with coagulation disorders or those who require concomitant use of anticoagulant or anti- platelet therapy during the treatment phase of the study.
  • 11. Patients with acetaminophen allergies resulting in anaphylaxis
  • 12. Current use of the medication probenecid
  • 13. Current use of the medication Pentoxifylline
  • 14. History of aspirin induced asthma.
  • 15. Known history of opioid dependence, abuse, or addiction.
  • 16. Bilateral IMN of the femurs

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

St. Louis University,

David Greenberg, MD, PRINCIPAL_INVESTIGATOR, St. Louis University

Study Record Dates

2026-12-31