Sex Differences in the Response to Abstinence From Alcohol.

Description

In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that abstinence affects drinking differently in women compared to men. In the present study, the investigators propose to study how men and women respond to abstinence, and whether this information can be used to improve intervention and prevention strategies.

Conditions

Alcohol Use Disorder

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Study Overview

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Study Details

Study overview

In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that abstinence affects drinking differently in women compared to men. In the present study, the investigators propose to study how men and women respond to abstinence, and whether this information can be used to improve intervention and prevention strategies.

Sex Differences in the Response to Abstinence From Alcohol.

Sex Differences in the Response to Abstinence From Alcohol.

Condition
Alcohol Use Disorder
Intervention / Treatment

-

Contacts and Locations

Indianapolis

University Hospital, Indianapolis, Indiana, United States, 46202

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Moderate social drinkers
  • * Able to understand/complete questionnaires and procedures in English
  • * Body mass index (BMI) between 18.5 and 32 kg/m2
  • * Have venous access sufficient to allow blood sampling
  • * Pregnant or breast-feeding women, or women who intend to become pregnant
  • * Do not attest to using accepted forms of birth control for the infusion phase of the study
  • * Current treatment for, or desire to be treated for, any substance use disorder or court ordered to not drink alcohol
  • * History of significant adverse reaction to alcohol
  • * Medical disorders or other conditions such as alcohol withdrawal seizures or delirium tremens that may influence study outcome or participant safety
  • * Medications (past 30 days) that could influence data or participant safety (e.g. antidepressants, antipsychotics, benzodiazepines, etc.) as determined by investigators
  • * DSM 5 Disorders (non AUD) or current/history of neurological disease of cerebral origin, or head injury with \> 20 min loss of consciousness
  • * Positive breath alcohol reading on arrival at any study visit
  • * Actively suicidal (for example, any suicide attempts within the past year or any current suicidal intent, including a plan) or are at serious suicidal risk, by clinical judgment of the investigator
  • * Any condition for which the principal investigators determine it is unsafe or not prudent to enroll

Ages Eligible for Study

21 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Indiana University,

Martin H Plawecki, MD, PhD, PRINCIPAL_INVESTIGATOR, Psychiatry, Indiana University School of Medicine

Melissa A Cyders, PhD, PRINCIPAL_INVESTIGATOR, Psychology, Indiana University-Purdue University at Indianapolis

Study Record Dates

2025-08-31