Positron Emission Tomography (PET) Imaging of Thrombosis

Description

The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in the left atrial appendage of patients with atrial fibrillation, and thereby may provide a non-invasive alternative to the current standard-of-care methods.

Conditions

Atrial Fibrillation, COVID-19, Cancer, Thrombosis

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Study Overview

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Study Details

Study overview

The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in the left atrial appendage of patients with atrial fibrillation, and thereby may provide a non-invasive alternative to the current standard-of-care methods.

Preliminary Evaluation of [64Cu]FBP8 in Healthy Individuals and Subjects With Known or at Risk of Developing Thrombosis

Positron Emission Tomography (PET) Imaging of Thrombosis

Condition
Atrial Fibrillation
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects less than 18 years of age;
  • * Electrical implants such as cardiac pacemaker or perfusion pump;
  • * Pregnant or breastfeeding (a negative STAT quantitative serum hCG pregnancy test is required for females having child-bearing potential before the subject can participate);
  • * Claustrophobic reactions;
  • * Subjects will be excluded if research-related radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months);
  • * Unable to lie comfortably on a bed inside the PET scanner;
  • * Subjects under direct or indirect (i.e. same department as PIs) supervision of the principal investigator;
  • * Body weight over the weight limit for the moving table (\> 300 lbs for the MRI table and \>441 lbs for the CT table);
  • * Metallic or electric implants contraindicated for MR-PET scanning when applicable;
  • * Does not have the ability to give written informed consent.
  • * Determined by the investigator(s) to be clinically unsuitable for the study (e.g. based on screening visit and/or during study procedures);
  • * Stroke within the last 3 months;
  • * Myocardial infarction within the last 3 months;
  • * Cardiac or major surgery within the last 3 months;
  • * History of chest pain within the last 6 weeks unless followed by a subsequent stress test or coronary angiography;
  • * History of syncope within the last 6 weeks;
  • * Heart rate persistently \>120 bpm or persistently \< 50 bpm;
  • * Presence of daytime pauses \> 3s

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Massachusetts General Hospital,

Ciprian Catana, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2026-01-30