RECRUITING

rTMS to Improve Cognition in Parkinson's

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease or atypical parkinsonism who are experiencing mild problems with their thinking ability.

Official Title

rTMS as a Cognitive Rehabilitation Approach in Veterans With Parkinson'sDisease

Quick Facts

Study Start:2020-04-01
Study Completion:2026-08-29
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03836950

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Veterans who seek services at Hines VA Hospital or Jesse Brown VA Medical Center
  2. * Diagnosis of PD or atypical parkinsonism as determined by a neurologist
  3. * Meet criteria for having mild cognitive impairment
  4. * Receiving stable (i.e., no changes in medication and medication dose) medication and who are expected to remain on stable medication for the duration of the RCT
  5. * Speak and read English
  6. * 50 years or older
  1. * Dementia
  2. * Failure to demonstrate decision making capacity
  3. * History of deep brain stimulation surgery
  4. * Severe depression
  5. * Resting head tremor
  6. * Dyskinesia that will interfere with collecting imaging data
  7. * Has congestive heart failure
  8. * Implanted cardiac pacemaker or defibrillator
  9. * Cochlear implant, nerve stimulator, or intracranial metal clips
  10. * Implanted medical pump
  11. * Increased intracranial pressure
  12. * History of claustrophobia
  13. * Metal in eyes/face, shrapnel/bullet remnants in brain
  14. * Participants at potential increased risk of seizure including those who have the following:
  15. * history (or family history) of seizure or epilepsy
  16. * history of stroke, head injury, or unexplained seizures
  17. * presence of other neurological disease that may be associated with an altered seizure threshold
  18. * such as CVA, cerebral aneurysm, dementia, increased intracranial pressure
  19. * Concurrent medication use such as tricyclic antidepressants, neuroleptic medications, any other drug known to lower seizure threshold
  20. * Secondary conditions that may significantly alter electrolyte balance or lower seizure threshold
  21. * No quantifiable motor threshold such that rTMS dosage cannot be accurately deter-mined

Contacts and Locations

Study Contact

Sandra L Kletzel, PhD BA
CONTACT
(708) 202-5735
Sandra.Kletzel@va.gov
Elyse R Walsh, DPT
CONTACT
(708) 968-0427
elyse.walsh@va.gov

Principal Investigator

Sandra L. Kletzel, PhD BA
PRINCIPAL_INVESTIGATOR
Edward Hines Jr. VA Hospital, Hines, IL

Study Locations (Sites)

Jesse Brown VA Medical Center, Chicago, IL
Chicago, Illinois, 60612
United States
Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, 60141-3030
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Sandra L. Kletzel, PhD BA, PRINCIPAL_INVESTIGATOR, Edward Hines Jr. VA Hospital, Hines, IL

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-04-01
Study Completion Date2026-08-29

Study Record Updates

Study Start Date2020-04-01
Study Completion Date2026-08-29

Terms related to this study

Keywords Provided by Researchers

  • rTMS
  • Parkinson's disease
  • mild cognitive impairment
  • executive function
  • neuromodulation
  • functional connectivity

Additional Relevant MeSH Terms

  • Parkinson's Disease
  • Mild Cognitive Impairment