rTMS to Improve Cognition in Parkinson's

Description

The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease or atypical parkinsonism who are experiencing mild problems with their thinking ability.

Conditions

Parkinson's Disease, Mild Cognitive Impairment

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Study Overview

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Study Details

Study overview

The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease or atypical parkinsonism who are experiencing mild problems with their thinking ability.

rTMS as a Cognitive Rehabilitation Approach in Veterans With Parkinson'sDisease

rTMS to Improve Cognition in Parkinson's

Condition
Parkinson's Disease
Intervention / Treatment

-

Contacts and Locations

Chicago

Jesse Brown VA Medical Center, Chicago, IL, Chicago, Illinois, United States, 60612

Hines

Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois, United States, 60141-3030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Veterans who seek services at Hines VA Hospital or Jesse Brown VA Medical Center
  • * Diagnosis of PD or atypical parkinsonism as determined by a neurologist
  • * Meet criteria for having mild cognitive impairment
  • * Receiving stable (i.e., no changes in medication and medication dose) medication and who are expected to remain on stable medication for the duration of the RCT
  • * Speak and read English
  • * 50 years or older
  • * Dementia
  • * Failure to demonstrate decision making capacity
  • * History of deep brain stimulation surgery
  • * Severe depression
  • * Resting head tremor
  • * Dyskinesia that will interfere with collecting imaging data
  • * Has congestive heart failure
  • * Implanted cardiac pacemaker or defibrillator
  • * Cochlear implant, nerve stimulator, or intracranial metal clips
  • * Implanted medical pump
  • * Increased intracranial pressure
  • * History of claustrophobia
  • * Metal in eyes/face, shrapnel/bullet remnants in brain
  • * Participants at potential increased risk of seizure including those who have the following:
  • * history (or family history) of seizure or epilepsy
  • * history of stroke, head injury, or unexplained seizures
  • * presence of other neurological disease that may be associated with an altered seizure threshold
  • * such as CVA, cerebral aneurysm, dementia, increased intracranial pressure
  • * Concurrent medication use such as tricyclic antidepressants, neuroleptic medications, any other drug known to lower seizure threshold
  • * Secondary conditions that may significantly alter electrolyte balance or lower seizure threshold
  • * No quantifiable motor threshold such that rTMS dosage cannot be accurately deter-mined

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Sandra L. Kletzel, PhD BA, PRINCIPAL_INVESTIGATOR, Edward Hines Jr. VA Hospital, Hines, IL

Study Record Dates

2026-08-29