Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: * to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at reference centers. * patient outcome will be evaluated in terms of overall survival (OS), disease-free survival (DFS), crude cumulative incidence (CCI) of local recurrence (LR) and distant metastasis (DM). Secondary Objectives: * to estimate the efficacy and safety of surgical treatment, including extended surgical approach to primary RPS; * to prospectively evaluate the impact of multimodality therapy, including radiation therapy and chemotherapy; * to identify clinical, radiological and pathological characteristics that may influence the oncological outcome or may be used as predictors of LR/DM/OS. These may be important biomarkers of disease; * to utilize collected pathological material for research collaborations.
Retroperitoneal Sarcoma
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: * to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at reference centers. * patient outcome will be evaluated in terms of overall survival (OS), disease-free survival (DFS), crude cumulative incidence (CCI) of local recurrence (LR) and distant metastasis (DM). Secondary Objectives: * to estimate the efficacy and safety of surgical treatment, including extended surgical approach to primary RPS; * to prospectively evaluate the impact of multimodality therapy, including radiation therapy and chemotherapy; * to identify clinical, radiological and pathological characteristics that may influence the oncological outcome or may be used as predictors of LR/DM/OS. These may be important biomarkers of disease; * to utilize collected pathological material for research collaborations.
REtroperitoneal SArcoma Registry: an International Prospective Initiative
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University of Southern California (USC), Los Angeles, California, United States, 90033
Mayo Clinic, Jacksonville, Florida, United States, 32224
Moffitt Cancer Center, Tampa, Florida, United States, 33612
Winship Cancer Institute, Emory, Georgia, United States, 30322
Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts, United States, 02115
The Ohio State University, Columbus, Ohio, United States, 43210
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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18 Years to
ALL
No
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano,
Alessandro Gronchi, MD, PRINCIPAL_INVESTIGATOR, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Marco Fiore, MD, STUDY_DIRECTOR, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
2030-12-31