This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of care therapy with the ultimate goal of being able to approve new targeted therapies in this setting. In addition, the protocol includes non-match sub-studies which will include all screened patients not eligible for any of the biomarker-driven sub-studies.
Previously Treated Non-Small Cell Lung Cancer
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of care therapy with the ultimate goal of being able to approve new targeted therapies in this setting. In addition, the protocol includes non-match sub-studies which will include all screened patients not eligible for any of the biomarker-driven sub-studies.
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
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Veterans Administration Medical Center - Birmingham, Birmingham, Alabama, United States, 35233
University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States, 36688
Alaska Oncology and Hematology LLC, Anchorage, Alaska, United States, 99508
Anchorage Oncology Centre, Anchorage, Alaska, United States, 99508
Katmai Oncology Group, Anchorage, Alaska, United States, 99508
Providence Alaska Medical Center, Anchorage, Alaska, United States, 99508
Fairbanks Memorial Hospital, Fairbanks, Alaska, United States, 99701
CTCA at Western Regional Medical Center, Goodyear, Arizona, United States, 85338
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas, United States, 72401
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States, 72205
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
No
SWOG Cancer Research Network,
Hossein Borghaei, STUDY_CHAIR, SWOG Cancer Research Network
2029-01-28