Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

Description

The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients undergoing arthroscopic knee surgery, and 2) whether patients' characteristics (gender, pre-operative knee symptoms, workers compensation status and employment status) affect pain level following surgery or medication usage.

Conditions

Knee Injuries, Pain, Postoperative, Opioid Use

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Study Overview

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Study Details

Study overview

The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients undergoing arthroscopic knee surgery, and 2) whether patients' characteristics (gender, pre-operative knee symptoms, workers compensation status and employment status) affect pain level following surgery or medication usage.

The Effects of Combination Therapy of Opioids Versus Non-Opioids on Postoperative Pain Management After Knee Arthroscopic Surgery: A Prospective Randomized Controlled Study

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

Condition
Knee Injuries
Intervention / Treatment

-

Contacts and Locations

Fargo

Sanford Health, Fargo, North Dakota, United States, 58122

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Subjects ≥ 18 years of age through ≤ 80 years of age
  • 2. Subjects undergoing elective arthroscopic knee surgery, to include partial meniscectomy, chondroplasty, or loose body removal.
  • 1. Previously enrolled in this study (enrolled for contralateral knee in this study)
  • 2. Knee arthroscopy patients scheduled for knee ligament reconstructions
  • 3. Bilateral knee arthroscopy
  • 4. History of chronic opioid use or long-term analgesic therapy
  • 5. Documented or suspected substance abuse
  • 6. Documented or suspected chronic pain syndrome
  • 7. Any known allergy or adverse reaction or contraindication to the components of hydrocodone, acetaminophen, or ibuprofen
  • 8. History or symptoms of any significant medical problem in the last year (i.e., arrhythmia, impaired cardiovascular function, gastrointestinal bleeding, liver disease, renal disease)
  • 9. With active peptic ulcer disease (history of severe heartburn)
  • 10. Symptoms of infection with initial enrollment
  • 11. Pregnant or nursing
  • 12. Diagnosis of cognitive impairment
  • 13. Unable or unwilling to provide informed consent for surgery or enrollment in this clinical study
  • 14. Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by Institutional Review Board) and agree to abide by the study restrictions.
  • 15. Patient refusal
  • 16. Currently taking Coumadin, Plavix, anticoagulation medications, or medications that increase bleeding, with the exception of ASA 81mg.
  • 17. Patients with other medical or psychological health conditions that preclude them from either receiving the intervention or returning for follow-up visits.
  • 18. Alcoholism

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Sanford Health,

Bruce Piatt, MD, PRINCIPAL_INVESTIGATOR, Sanford Health

Study Record Dates

2026-01