Alveolar Macrophage Programming Following Endotoxin Exposure

Description

The histologic hallmarks of lung inflammation include accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).

Conditions

ARDS, Human

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Study Details

Study overview

The histologic hallmarks of lung inflammation include accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).

Alveolar Macrophage Programming Following Endotoxin Exposure

Alveolar Macrophage Programming Following Endotoxin Exposure

Condition
ARDS, Human
Intervention / Treatment

-

Contacts and Locations

Denver

National Jewish Health, Denver, Colorado, United States, 80206

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Written, informed consent
  • 2. Age 18-50
  • 1. Current or recent illness (past 2 weeks)
  • 2. Presence or prior history of cardiac, pulmonary or systemic disease
  • 3. Bleeding disorder, use of systemic anticoagulants or antiplatelet therapy
  • 4. American Society of Anesthesiology (ASA) class 2 or greater
  • 5. Immunocompromised state (HIV, immunoglobulin deficiency, systemic immunosuppressants)
  • 6. Use of any inhaled substance, including tobacco, marijuana, e-cigarrettes, cocaine, methamphetamines, or toxic vapors in the past 3 months or greater than 10 pack-year smoking history
  • 7. Alcohol use disorder or greater than 7 drinks/week for women or greater than 14 drinks/week for men in the past 3 months
  • 8. Allergy or prior adverse reaction to lidocaine, midazolam or fentanyl
  • 9. Abnormal spirometry or electrocardiogram at time of screening
  • 10. Pregnant (based on urine pregnancy test) or breast feeding

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

National Jewish Health,

Study Record Dates

2032-07