Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV

Description

Cigarette smoking is more prevalent (50-70%) in persons living with HIV in the U.S. when compared with the general population and is linked to increased rates of heart disease, lung diseases and infections, and lung cancers. Because of their high levels of nicotine dependence, low quit rates, and familiarity with harm reduction, HIV-positive smokers may view the use of alternative nicotine delivery products, such as electronic cigarettes (ECs), as an attractive option for reducing and eventually stopping combustible cigarette use. However, little is known about the health effects of electronic cigarette use in HIV-positive smokers. Some studies have shown that electronic cigarette use was associated with increased confidence to quit smoking in the general population. The primary objectives of this project are to examine whether HIV-positive smokers, who are unwilling or unable to quit smoking, will substitute an electronic cigarette for regular cigarettes, and to examine whether there are any changes in heart and lung health in HIV-positive smokers who switch from regular cigarettes to electronic cigarettes.

Conditions

HIV

Study Overview

Study Details

Study overview

Cigarette smoking is more prevalent (50-70%) in persons living with HIV in the U.S. when compared with the general population and is linked to increased rates of heart disease, lung diseases and infections, and lung cancers. Because of their high levels of nicotine dependence, low quit rates, and familiarity with harm reduction, HIV-positive smokers may view the use of alternative nicotine delivery products, such as electronic cigarettes (ECs), as an attractive option for reducing and eventually stopping combustible cigarette use. However, little is known about the health effects of electronic cigarette use in HIV-positive smokers. Some studies have shown that electronic cigarette use was associated with increased confidence to quit smoking in the general population. The primary objectives of this project are to examine whether HIV-positive smokers, who are unwilling or unable to quit smoking, will substitute an electronic cigarette for regular cigarettes, and to examine whether there are any changes in heart and lung health in HIV-positive smokers who switch from regular cigarettes to electronic cigarettes.

Health Effects of the Standardized Research E-Cigarette for Harm Reduction in Smokers With HIV

Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV

Condition
HIV
Intervention / Treatment

-

Contacts and Locations

Providence

Brown University School of Public Health, Providence, Rhode Island, United States, 02912

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * diagnosed with and engaged in care for HIV (defined as at least one HIV clinic medical appointment within the past six month period)
  • * at least 18 years of age
  • * smoke at least 5 cigarettes per day for longer than one year
  • * exhaled carbon monoxide (CO) level greater than 5 at BL
  • * intention to quit smoking in the next 30 days
  • * currently using pharmacotherapy for smoking cessation
  • * currently using electronic cigarettes more than 2 days/week
  • * unstable medical or psychiatric condition (defined as hospitalization)
  • * medical contraindications to nicotine (unstable angina, uncontrolled hypertension, or recent cardiovascular event, including hospitalization)
  • * psychotic symptoms
  • * substance use disorder other than nicotine dependence
  • * past-month suicidal ideation or past-year suicide attempt
  • * pregnant or nursing.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Brown University,

PATRICIA A CIOE, PhD, PRINCIPAL_INVESTIGATOR, Brown University

Study Record Dates

2024-12-30