Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Description

It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.

Conditions

Obesity, Morbid

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Study Overview

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Study Details

Study overview

It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.

Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Condition
Obesity, Morbid
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 559055

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * BMI 40 - 50 kg/m2.
  • * Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery
  • * Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
  • * Active coronary artery disease
  • * Participation in structured exercise (\>2 times per week for 30 minutes or longer)
  • * Smoking
  • * Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)
  • * Renal insufficiency (serum creatinine \> 1.5mg/dl)
  • * Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L)
  • * Pregnancy or breastfeeding.

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Michael D Jensen, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2025-05