Gamma Induction for Alzheimer's Disease

Eligibility Criteria

• * Clinical Diagnosis of early to moderate AD\*
• * Mini Mental State Examination (MMSE) ≥ 18
• * Clinical Dementia Rating (CDR) ≥ 0.5
• * Demonstration or history of memory impairments.
• * Confirmation of diagnosis will be made by the study MD based on a holistic consideration of the participant's cognitive evaluation and history.
• * Amyloid positive PET imaging
• * At least 45 years old
• * On a stable dose of medications for memory loss including cholinesterase inhibitors (e.g. donepezil, rivastigmine or memantine) as defined as 6 consecutive weeks of treatment at an unchanging dose
• * Minimum of completed 8th grade education
• * No history of intellectual disability
• * Current history of poorly controlled migraines including chronic medication for migraine prevention
• * Current or past history of any neurological disorder other than dementia, such as epilepsy, stroke (cortical stroke), progressive neurologic disease (e.g. multiple sclerosis) or intracranial brain lesions; and history of previous neurosurgery or head trauma that resulted in residual neurologic impairment.
• * Non-cortical disease such as confluence white matter changes (including lacunar infarcts \< 1cm) and asymptomatic, subacute, cerebellar infarcts may be included upon review of a medically responsible neurologist.
• * Past or current history of major depression, bipolar disorder or psychotic disorders, or any other major psychiatric condition.
• * Contraindication for undergoing MRI or receiving TMS or tACS,
• * \>50 mSv of radiation exposure for research within the past year (PET imaging exclusion)
• * History of fainting spells of unknown or undetermined etiology that might constitute seizures.
• * History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or immediate (1st degree relative) family history of epilepsy; with the exception of a single seizure of benign etiology (e.g. febrile seizure) in the judgment of the investigator.
• * Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.).
• * Metal implants (excluding dental fillings) or devices such as pacemaker, medication pump, nerve stimulator, TENS unit, ventriculo-peritoneal shunt, cochlear implant, unless cleared by the study MD.
• * Substance abuse or dependence within the past six months.
• * Medications will be reviewed by the responsible MD and a decision about inclusion will be made based on the following: The patient's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination of CNS active drugs.
• * All female participants that are pre-menopausal will be required to have a pregnancy test; any participant who is pregnant or breastfeeding will not be enrolled in the study.
• * Subjects who, in the investigator's opinion, might not be suitable for the study
• * A hair style or head dress that prevents electrode contact with the scalp or would interfere with the stimulation (for example: thick braids, hair weave, afro, wig)