PRISM Intervention Study

Description

This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as "minimally verbal" at age 6, by empirically developing a two-stage, 20-week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status of children with ASD by providing the best intervention (DTT, JASPER and CET) for children who need it (leading to individualized sequences of intervention), only when it is needed (potentially reducing burden on children).

Conditions

Autism Spectrum Disorder

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Study Overview

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Study Details

Study overview

This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as "minimally verbal" at age 6, by empirically developing a two-stage, 20-week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status of children with ASD by providing the best intervention (DTT, JASPER and CET) for children who need it (leading to individualized sequences of intervention), only when it is needed (potentially reducing burden on children).

Personalized, Responsive Intervention Sequences for Minimally Verbal Children With Autism

PRISM Intervention Study

Condition
Autism Spectrum Disorder
Intervention / Treatment

-

Contacts and Locations

Los Angeles

UCLA, Los Angeles, California, United States, 90095

Rochester

University of Rochester, Rochester, New York, United States, 14642

Eugene

University of Oregon, Eugene, Oregon, United States, 97403

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * children meeting ADOS-2 criteria for ASD,
  • * age 36-59 months
  • * who have had \> 3 months early intervention/preschool (to ensure that children already have been exposed to some community interventions) and
  • * use \< 20 functional words (i.e., non-echoed, non-scripted).
  • * stable medication over the past 6 months, and
  • * nonverbal mental age of \>12 months on the Mullen Scales of Early Learning (visual reception and fine motor subscales).
  • * We will exclude children who have sensory and motor impairments (e.g., visual impairment, deaf or hard of hearing) and with known genetic syndromes (e.g., Down Syndrome).
  • * We will not exclude on the basis of AAC exposure, but expect few will be exposed at these ages.

Ages Eligible for Study

36 Months to 59 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Study Record Dates

2026-03-31