RECRUITING

Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The RAATE proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. There are three main objectives of the protocol: 1) to determine if a physical activity intervention tailored to older African American adults is effective in modifying cognitive function associated with Alzheimer's Disease, 2) to determine if a physical activity intervention tailored to older African American adults is effective in modifying brain function and structure associated with Alzheimer's Disease, and 3) to determine if a physical activity promotion intervention tailored to African American adults is effective at enhancing physiological parameters. The primary endpoints for the study are episodic memory and executive functioning. The secondary outcomes include anthropometry, blood pressure, brain activation, cerebral blood flow, volume of whole brain and white matter hyperintensities, cardiorespiratory fitness, objectively measured physical activity, circulating hormones, and telomere length.

Official Title

Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"

Quick Facts

Study Start:2019-08-09
Study Completion:2026-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03890861

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. self- identify as African American
  2. 2. 60 years and older
  3. 3. willing to accept randomization
  4. 4. willing to attend group sessions
  5. 5. lacking plans to move during the study period
  6. 6. free of conditions that would make regular exercise unsafe (e.g. uncontrolled asthma, severe sickle cell disease, etc.)
  7. 7. not engaged in regular physical activity
  8. 8. Short Physical Performance Battery score \>/= 4
  9. 9. physically capable of exercise,
  1. 1. cognitive impairment that would interfere with participating in group interactions
  2. 2. unwilling to give written informed consent
  3. 3. inability to attend group sessions
  4. 4. conditions that prevent regular exercise
  5. 5. conditions that the medical or principal investigator determine to warrant exclusion

Contacts and Locations

Study Contact

Melissa Harris, PhD
CONTACT
225763091
Melissa.Harris@pbrc.edu

Principal Investigator

Robert L Newton, Jr., PhD
PRINCIPAL_INVESTIGATOR
Pennington Biomedical Research Center
Owen L Carmichael, PhD
PRINCIPAL_INVESTIGATOR
Pennington Biomedical Research Center

Study Locations (Sites)

Pennington Biomedical Research Center
Baton Rouge, Louisiana, 70808
United States

Collaborators and Investigators

Sponsor: Pennington Biomedical Research Center

  • Robert L Newton, Jr., PhD, PRINCIPAL_INVESTIGATOR, Pennington Biomedical Research Center
  • Owen L Carmichael, PhD, PRINCIPAL_INVESTIGATOR, Pennington Biomedical Research Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-08-09
Study Completion Date2026-11

Study Record Updates

Study Start Date2019-08-09
Study Completion Date2026-11

Terms related to this study

Keywords Provided by Researchers

  • African American
  • Aging
  • Physical activity
  • Cognition
  • Prevention

Additional Relevant MeSH Terms

  • Dementia, Alzheimer Type