RECRUITING

Biomarkers of Acute Stroke in Clinic

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed study will investigate the clinical use of the ISCDX test that may differentiate between diverse stroke etiologies as listed below: Aim 1: Differentiate between cardioembolic and large artery atherosclerotic ischemic strokes, when hemorrhagic stroke is ruled out, as defined by TOAST classification of subtypes of acute ischemic stroke. Aim 2: In cases of ischemic strokes of unknown or "cryptogenic" etiology, determine the ability of biomarker blood tests to predict etiology between cardioembolic and large artery atherosclerotic.

Official Title

Biomarkers of Acute Stroke in Clinic

Quick Facts

Study Start:2019-04-01
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03897478

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients \>18 and \< 80 years of age.
  2. * Signs and symptoms suggestive of AIS due to cardioembolic, large vessel, or unknown etiology according to TOAST criteria.
  3. * Arrival to the ED within 30 hours of symptom onset or last known normal time and clinical evidence suggesting Acute Ischemic Stroke.
  4. * Head CT or MRI ruling out other pathology such as vascular malformation, hemorrhage, tumor or abscess which would likely be responsible for presenting neurologic symptoms
  5. * Informed consent obtained
  1. * Any central nervous system infection, i.e. meningitis or encephalitis in the past 30 days
  2. * Any form of head trauma, stroke or intracranial hemorrhage in the past 30 days
  3. * Any history of primary or metastatic brain cancer
  4. * Active cancer defined as a diagnosis of cancer, within 6 months before enrollment, any treatment for cancer within the previous 6 months, or recurrent or metastatic cancer.
  5. * Autoimmune diseases: such as lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis
  6. * Active chronic infectious diseases (eg. HIV/AIDS, hepatitis C)
  7. * Any underlying medical condition which in the opinion of the investigator would prohibit the patient from providing informed consent
  8. * Major surgery within three months prior to the index event
  9. * Signs and symptoms suggestive of (i) AIS due to small vessel occlusion (lacune) and other known etiology according to TOAST criteria, as well as (ii) stroke mimics, transient ischemic attacks, or transient neurological events.

Contacts and Locations

Study Contact

Judy Morgan, MBA, CCRC
CONTACT
513-827-9106
judy@iscdx.com
Jeff June
CONTACT
513-827-9106
jeff.june@iscdx.com

Study Locations (Sites)

Ohio Health Riveside Methodist Hospital
Columbus, Ohio, 43214
United States

Collaborators and Investigators

Sponsor: Ischemia Care LLC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-04-01
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2019-04-01
Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

  • Ischemic stroke
  • Atrial fibrillation
  • Transient neurological event
  • Cryptogenic stroke
  • Gene expression
  • RNA
  • Anticoagulant
  • NOAC
  • Implantable cardiac monitor
  • Point of care
  • tPA
  • Thrombectomy
  • Cardiac monitoring

Additional Relevant MeSH Terms

  • Ischemic Stroke
  • Ischemia
  • Atrial Fibrillation
  • Transient Ischemic Attack
  • Transient Cerebrovascular Events
  • Thrombotic Stroke
  • Stroke
  • Stroke, Acute
  • Stroke, Ischemic
  • Stroke, Complication
  • Stroke of Basilar Artery
  • Atherosclerosis
  • Atheroma
  • Cardioembolic Stroke
  • Cardiomyopathies
  • Cardiovascular Stroke
  • Thromboembolism