Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability

Description

The study objectives of this projects are to examine the hypothesis that the sympathetic and blood pressure responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease, via altering the sensitivity of the muscle afferent receptors.

Conditions

PAD

Study Overview

Study Details

Study overview

The study objectives of this projects are to examine the hypothesis that the sympathetic and blood pressure responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease, via altering the sensitivity of the muscle afferent receptors.

Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability

Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability

Condition
PAD
Intervention / Treatment

-

Contacts and Locations

Hershey

Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States, 17033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Capable of giving informed consent
  • * Any race or ethnicity
  • * Men and women age 21- 85 years (inclusive)
  • * Fluent in written and spoken English
  • * Diagnosed with PAD (i.e., ankle-brachial index below 0.9)
  • * Fontaine stage II or less - no pain while resting
  • * Satisfactory history and physical exam
  • * Satisfactory history and physical examination
  • * Free of acute medical conditions
  • * Age \< 21 years
  • * Pregnant or nursing women
  • * Decisional impairment
  • * Prisoners
  • * History of CAD with symptoms of unstable angina or myocardial infarction (\<6 months)
  • * History of epilepsy or seizure disorders

Ages Eligible for Study

21 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Milton S. Hershey Medical Center,

Jian Cui, PRINCIPAL_INVESTIGATOR, Penn State College of Medicine

Study Record Dates

2025-07