Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

Description

The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.

Conditions

Mechanical Ventilation Complication

Study Overview

Study Details

Study overview

The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.

A Phase III Randomized Trial Comparing the Effects of Volume Support and Assist Control Mode Ventilation on Ventilator-Free Days and Diaphragmatic Atrophy

Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

Condition
Mechanical Ventilation Complication
Intervention / Treatment

-

Contacts and Locations

Chicago

The University of Chicago Medical Center, Chicago, Illinois, United States, 60637

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. pregnancy
  • 2. cardiopulmonary arrest
  • 3. history of diaphragmatic paralysis or neuromuscular disease
  • 4. chronic obstructive pulmonary disease (COPD) or asthma exacerbation with evidence of auto-PEEPing requiring intubation
  • 5. neuromuscular blockade
  • 6. expectation to be liberated from ventilator in \< 24 hours
  • 7. history of mechanical ventilation in the last 6 months
  • 8. presence of tracheostomy
  • 9. high cervical spine injury

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Chicago,

John P Kress, MD, STUDY_DIRECTOR, University of Chicago

Bhakti Patel, MD, PRINCIPAL_INVESTIGATOR, University of Chicago

Roger Struble, MD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2026-01