RECRUITING

Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

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Conditions

Mechanical Ventilation ComplicationDiaphragm AtrophyVentilator Induced Diaphragm DysfunctionMechanical VentilationVolume Support ModeAssist Control ModeDiaphragm Thickening FractionIntubationDeliriumVentilator-Free Days

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.

Official Title

A Phase III Randomized Trial Comparing the Effects of Volume Support and Assist Control Mode Ventilation on Ventilator-Free Days and Diaphragmatic Atrophy

Quick Facts

Study Start:2019-03-04
Study Completion:2026-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03901924

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. 1. pregnancy
  2. 2. cardiopulmonary arrest
  3. 3. history of diaphragmatic paralysis or neuromuscular disease
  4. 4. chronic obstructive pulmonary disease (COPD) or asthma exacerbation with evidence of auto-PEEPing requiring intubation
  5. 5. neuromuscular blockade
  6. 6. expectation to be liberated from ventilator in \< 24 hours
  7. 7. history of mechanical ventilation in the last 6 months
  8. 8. presence of tracheostomy
  9. 9. high cervical spine injury

Contacts and Locations

Study Contact

Bhakti Patel, MD
CONTACT
773-702-0902
bpatel@bsd.uchicago.edu
Anne S Pohlman, MSN
CONTACT
773-702-3804
apohlman@bsd.uchicago.edu

Principal Investigator

John P Kress, MD
STUDY_DIRECTOR
University of Chicago
Bhakti Patel, MD
PRINCIPAL_INVESTIGATOR
University of Chicago
Roger Struble, MD
PRINCIPAL_INVESTIGATOR
University of Iowa

Study Locations (Sites)

The University of Chicago Medical Center
Chicago, Illinois, 60637
United States
University of Iowa
Iowa City, Iowa, 52242
United States

Collaborators and Investigators

Sponsor: University of Chicago

  • John P Kress, MD, STUDY_DIRECTOR, University of Chicago
  • Bhakti Patel, MD, PRINCIPAL_INVESTIGATOR, University of Chicago
  • Roger Struble, MD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-03-04
Study Completion Date2026-01

Study Record Updates

Study Start Date2019-03-04
Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

  • Diaphragm Atrophy
  • Ventilator Induced Diaphragm Dysfunction
  • Mechanical Ventilation
  • Volume Support Mode
  • Assist Control Mode
  • Diaphragm Thickening Fraction
  • Intubation
  • Delirium
  • Ventilator-Free Days

Additional Relevant MeSH Terms

  • Mechanical Ventilation Complication