COMPLETED

Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research study is to determine whether early administration of Dexrazoxane prevents Doxorubicin induced cardiotoxicity.

Official Title

Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane in Patients With Breast Cancer

Quick Facts

Study Start:2021-09-14
Study Completion:2025-06-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT03930680

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Women,
  2. * Age 18-65,
  3. * Not pregnant, Not currently breast feeding
  4. * No current illness,
  1. * Pregnancy, currently breast feeding
  2. * Current illness,
  3. * History of cardiac, or renal disease

Contacts and Locations

Principal Investigator

Hui-Ming Chang, MD,MPH
PRINCIPAL_INVESTIGATOR
University of Arkansas

Study Locations (Sites)

University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States

Collaborators and Investigators

Sponsor: University of Arkansas

  • Hui-Ming Chang, MD,MPH, PRINCIPAL_INVESTIGATOR, University of Arkansas

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-09-14
Study Completion Date2025-06-11

Study Record Updates

Study Start Date2021-09-14
Study Completion Date2025-06-11

Terms related to this study

Keywords Provided by Researchers

  • Dexrazoxane
  • Topoisomerase 2b
  • Human
  • Doxorubicin cardio-toxicity
  • Cardio-oncology
  • Onco-cardiology
  • Prevention of cardio-toxicity by doxorubicin
  • Early administration of dexrazoxane

Additional Relevant MeSH Terms

  • Degradation of Top2b and Top2a in Human by Dexrazoxane
  • Time Course and Degradation of Top2b in Human by Dexrazoxane
  • Effects of Dexrazoxane on Healthy Human