RECRUITING

Gene Expression Changes In Young and Geriatric Skin

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.

Official Title

Gene Expression Changes in Young and Geriatric Skin

Quick Facts

Study Start:2019-09-06
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03932162

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male/Female
  2. * White skin (Fitzpatrick types I and II)
  3. * Age 21-30 or 65 and older
  4. * Able to comprehend procedures/risks
  1. * Known photosensitivity
  2. * Currently on photosensitizing medications
  3. * Diabetes Mellitus
  4. * History of abnormal scarring
  5. * History of skin infections
  6. * Known allergy to lidocaine local anesthetic
  7. * Pregnancy or nursing
  8. * Other serious health issues

Contacts and Locations

Study Contact

Manager, Clinical Research Operations
CONTACT
937-245-7500
pturesearch@wrightstatephysicians.org
Regulatory Specialist
CONTACT
937-245-7500
pturesearch@wrightstatephysicians.org

Principal Investigator

Jeffrey B Travers, MD, PhD
PRINCIPAL_INVESTIGATOR
Wright State University

Study Locations (Sites)

Wright State Physicians
Fairborn, Ohio, 45324
United States

Collaborators and Investigators

Sponsor: Wright State University

  • Jeffrey B Travers, MD, PhD, PRINCIPAL_INVESTIGATOR, Wright State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-09-06
Study Completion Date2025-12

Study Record Updates

Study Start Date2019-09-06
Study Completion Date2025-12

Terms related to this study

Additional Relevant MeSH Terms

  • UVB Phototherapy Burn
  • Insulin-like Growth Factor 1
  • Aging