Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports. Up to 30% of individuals under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been associated with degeneration of the articular cartilage and increased rates of meniscal tears, increasing the risk of post-traumatic osteoarthritis (PTOA), additional surgical procedures, reduced physical function and quality of life. As such, strategies to reduce ACLR failure, particularly in young active individuals, are critical to improving short and long-term outcomes after ACL rupture. There is ongoing debate about the optimal graft choice and reconstructive technique. Three autograft options are commonly used, including the bone-patellar-tendon-bone (BPTB), quadriceps tendon (QT) and hamstring tendon (HT). Additionally, a lateral extra-articular tenodesis (LET) may provide greater stability to the ACLR; however, its effect on failure rate is unclear and surgery-induced lateral compartment OA is a concern. To definitively inform the choice of autograft and the need for a LET, this multicenter, international randomized clinical trial will randomly assign 1236 young, active patients at high risk of re-injury to undergo ACLR using BPTB or QT autograft with our without LET.
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports. Up to 30% of individuals under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been associated with degeneration of the articular cartilage and increased rates of meniscal tears, increasing the risk of post-traumatic osteoarthritis (PTOA), additional surgical procedures, reduced physical function and quality of life. As such, strategies to reduce ACLR failure, particularly in young active individuals, are critical to improving short and long-term outcomes after ACL rupture. There is ongoing debate about the optimal graft choice and reconstructive technique. Three autograft options are commonly used, including the bone-patellar-tendon-bone (BPTB), quadriceps tendon (QT) and hamstring tendon (HT). Additionally, a lateral extra-articular tenodesis (LET) may provide greater stability to the ACLR; however, its effect on failure rate is unclear and surgery-induced lateral compartment OA is a concern. To definitively inform the choice of autograft and the need for a LET, this multicenter, international randomized clinical trial will randomly assign 1236 young, active patients at high risk of re-injury to undergo ACLR using BPTB or QT autograft with our without LET.
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
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Stanford University, Redwood City, California, United States, 94063
University of California, San Francisco, San Francisco, California, United States, 94158
Med Center Health, Bowling Green, Kentucky, United States, 42101
University of Kentucky, Lexington, Kentucky, United States, 40504
Ochsner Clinic Foundation, Baton Rouge, Louisiana, United States, 70836
University of Michigan, Ann Arbor, Michigan, United States, 48109
University of Minnesota, Minneapolis, Minnesota, United States, 55455
Mayo Clinic, Rochester, Minnesota, United States, 55905
University of New Mexico, Albuquerque, New Mexico, United States, 87131
Hospital for Special Surgery, New York, New York, United States, 10021
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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14 Years to 25 Years
ALL
No
University of Pittsburgh,
James J Irrgang, PT PhD FAPTA, PRINCIPAL_INVESTIGATOR, University of Pittsburgh
Alan Getgood, MD FRCS, PRINCIPAL_INVESTIGATOR, Fowler Kennedy Sport Medicine Clinic, Western University, Department of Surgery
Volker Musahl, MD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh
Dianne M Bryant, PhD, PRINCIPAL_INVESTIGATOR, Western University, School of Physical Therapy & Department of Surgery
2025-03-30