Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

Description

A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on postpartum hypertension.

Conditions

Preeclampsia Severe, Preeclampsia Postpartum

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Study Overview

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Study Details

Study overview

A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on postpartum hypertension.

Preeclampsia And Nonsteroidal Drugs for Analgesia (PANDA): a Randomized Non Inferiority Trial

Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

Condition
Preeclampsia Severe
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Barnes Jewish Hospital, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Women at \> 23 weeks gestational age undergoing vaginal or cesarean delivery at Barnes-Jewish Hospital with:
  • * An antepartum diagnosis of preeclampsia with severe features
  • * Pre-eclampsia with severe features will be defined as:
  • * Elevated blood pressure ≥ 160/110, or
  • * Pre-eclampsia in the setting of thrombocytopenia (platelet count \< 100,000), or
  • * Impaired liver function (AST elevated to twice upper limit of normal), or
  • * Persistent epigastric pain, or
  • * Renal insufficiency (serum creatinine of 1.1 mg/dl or doubling of prior value), or
  • * Pulmonary edema, or
  • * New onset visual disturbance or headache unresponsive to therapy.
  • * NSAID allergy
  • * Allergy to acetaminophen
  • * Antihypertensive use in this pregnancy prior to 20 weeks gestation
  • * Chronic kidney disease or Acute kidney injury with Creatine clearance less than 60 mL/min
  • * Inability to obtain consent
  • * Opioid abuse disorder
  • * Peptic ulcer disease.

Ages Eligible for Study

to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington University School of Medicine,

Study Record Dates

2025-06-01