Role of the Sympathetic Nervous System in Rosacea

Description

Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic ("fight or flight") portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.

Conditions

Rosacea

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Study Overview

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Study Details

Study overview

Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic ("fight or flight") portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.

Role of the Sympathetic Nervous System in Rosacea

Role of the Sympathetic Nervous System in Rosacea

Condition
Rosacea
Intervention / Treatment

-

Contacts and Locations

Indianapolis

Indiana University, Indianapolis, Indiana, United States, 46202

Lexington

University of Kentucky, Lexington, Kentucky, United States, 40506

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects.
  • * Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders
  • * Current history of alcohol and/or drug abuse
  • * Known allergies or hypersensitivities to medications/drugs that are used in the protocol
  • * Current smoking or regular smoking within the last 2 years
  • * Body mass index \> 35 kg/m2
  • * Medications or supplements which are known to affect neural, cardiovascular, or muscular responses

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Kristen Metzler-Wilson,

Kristen Metzler-Wilson, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

2025-08