Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma

Eligibility Criteria

• * Histologically confirmed pancreatic adenocarcinoma
• * Borderline resectable pancreatic adenocarcinoma or locally advanced pancreatic adenocarcinoma
• * No evidence of extrapancreatic disease on diagnostic imaging
• * No evidence of invasion into the duodenum or stomach, as determined by EGD/EUS
• * No prior treatment (chemotherapy, biological therapy, or radiotherapy) for pancreatic cancer
• * No prior treatment with oxaliplatin, irinotecan, fluorouracil, or capecitabine
• * ECOG Performance Status of 0-1
• * No other malignancy within past five years (exceptions include basal cell carcinoma of the skin, cervical carcinoma in situ, and non-metastatic prostate cancer)
• * No evidence of second malignancy at the time of study entry
• * No interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung
• * No \> grade 2 sensory peripheral neuropathy
• * No uncontrolled seizure disorder, active neurological disease, or known CNS disease
• * No significant cardiac disease, including the following: unstable angina, New York Heart Association class II-IV congestive heart failure, myocardial infarction within six months prior to study enrollment
• * Not pregnant and not nursing
• * No other medical condition or reason that, in the opinion of the investigator, would preclude study participation
• * Laboratory parameters as follows:
• * Absolute neutrophil count ≥1,500/uL,
• * Platelet count ≥75,000/uL,
• * Hemoglobin ≥9 g,/dL,
• * Creatinine \<1.5 X ULN or estimated GFR \>30 ml/min,
• * Bilirubin \<1.5 X ULN,
• * AST and ALT \<3 X ULN,
• * Negative pregnancy test in women of childbearing potential
• * Able to be treated with SBRT only at the Smilow New Haven campus
• * Able to have fiducials placed in the pancreas
• * Failing to meet any of the Inclusion Criteria